PDB entry 3ioi

View 3ioi on RCSB PDB site
Description: Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (1GW)
Class: transferase
Keywords: GTA, ABO, cisAB mutant, AA(Gly)B, ROSSMANN FOLD, INHIBITOR, SEMI-CLOSED CONFORMATION, BLOOD GROUP ANTIGEN, GLYCOPROTEIN, GLYCOSYLTRANSFERASE, GOLGI APPARATUS, MANGANESE, MEMBRANE, METAL-BINDING, SECRETED, SIGNAL-ANCHOR, TRANSFERASE, TRANSMEMBRANE
Deposited on 2009-08-14, released 2010-04-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: 0.16
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histo-blood group ABO system transferase
    Species: Homo sapiens [TaxId:9606]
    Gene: ABO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16442
      • engineered (209)
      • engineered (211)
    Domains in SCOPe 2.05: d3ioia_
  • Heterogens: MN, SO4, 1GW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ioiA (A:)
maigefmvslprmvypqpkvltpcrkdvlvvtpwlapivwegtfnidilneqfrlqntti
gltvfaikkyvaflklfletaekhfmvghrvhyyvftdqpaavprvtlgtgrqlsvlevr
aykrwqdvsmrrmemisdfcerrflsevdylvcvdvdmefrdhvgveiltplfgtlhpgf
ygssreaftyerrpqsqayipkdegdfyyggaffggsvqevqrltrachqammvdqangi
eavwhdeshlnkyllrhkptkvlspeylwdqqllgwpavlrklrftavpknhqavrnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3ioiA (A:)
slprmvypqpkvltpcrkdvlvvtpwlapivwegtfnidilneqfrlqnttigltvfaik
kyvaflklfletaekhfmvghrvhyyvftdqpaavprvtlgtgrqlsvlevramrrmemi
sdfcerrflsevdylvcvdvdmefrdhvgveiltplfgtlhpgfygssreaftyerrpqs
qayipkdegdfyyggaffggsvqevqrltrachqammvdqangieavwhdeshlnkyllr
hkptkvlspeylwdqqllgwpavlrklrftavpk