SCOPe 2.06: Structural Classification of Proteins

PDB entry 3gxf

View 3gxf on RCSB PDB site
Description: Crystal structure of acid-beta-glucosidase with isofagomine at neutral pH
Class: hydrolase
Keywords: hydrolase, Alternative initiation, Disease mutation, Disulfide bond, Gaucher disease, Glycoprotein, Glycosidase, Ichthyosis, Lipid metabolism, Lysosome, Membrane, Sphingolipid metabolism
Deposited on 2009-04-02, released 2009-05-05
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.182
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.06: d3gxfa1, d3gxfa2
Chain 'B':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.06: d3gxfb1, d3gxfb2
Chain 'C':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.06: d3gxfc1, d3gxfc2
Chain 'D':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.06: d3gxfd1, d3gxfd2
Heterogens: PO4, NAG, GOL, IFM, HOH

PDB Chain Sequences:

Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxfA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxfB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxfC (C:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxfD (D:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq