PDB entry 3gnw

View 3gnw on RCSB PDB site
Description: HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c
Class: transferase
Keywords: 1,5-Benzodiazepines, Hepatitis C Virus, NS5b, Polymerase, Sulfone, Apoptosis, ATP-binding, Capsid protein, Cell membrane, Endoplasmic reticulum, Envelope protein, Fusion protein, Glycoprotein, Helicase, Host-virus interaction, Hydrolase, Interferon antiviral system evasion, Lipid droplet, Lipoprotein, Membrane, Metal-binding, Mitochondrion, Multifunctional enzyme, Nucleotide-binding, Nucleotidyltransferase, Nucleus, Oncogene, Palmitate, Phosphoprotein, Protease, Ribonucleoprotein, RNA replication, RNA-binding, RNA-directed RNA polymerase, Secreted, Serine protease, SH3-binding, Thiol protease, Transcription, Transcription regulation, Transferase, Transmembrane, Viral nucleoprotein, Virion
Deposited on 2009-03-18, released 2009-10-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: 0.169
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3gnwa_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (3-572)
      • expression tag (573)
    Domains in SCOPe 2.05: d3gnwb_
  • Heterogens: XNC, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gnwA (A:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3gnwA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gnwB (B:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3gnwB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhslsrarprl