PDB entry 3ggu

View 3ggu on RCSB PDB site
Description: HIV PR drug resistant patient's variant in complex with darunavir
Class: hydrolase
Keywords: darunvir, resistance, mutation score, HIV protease, TMC-114, HYDROLASE
Deposited on 2009-03-02, released 2009-08-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.206
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protease
    Species: Human immunodeficiency virus type 1 (BRU ISOLATE) [TaxId:11686]
    Gene: Gag-Pol, pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03367 (0-98)
      • engineered (9)
      • engineered (12)
      • engineered (15)
      • engineered (32)
      • engineered (35-36)
      • engineered (38)
      • engineered (44-45)
      • engineered (53-54)
      • engineered (61-62)
      • engineered (70)
      • engineered (72)
      • engineered (81)
      • engineered (83)
      • engineered (88-89)
      • engineered (92)
    Domains in SCOPe 2.06: d3ggua_
  • Chain 'B':
    Compound: Protease
    Species: Human immunodeficiency virus type 1 (BRU ISOLATE) [TaxId:11686]
    Gene: Gag-Pol, pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03367 (0-98)
      • engineered (9)
      • engineered (12)
      • engineered (15)
      • engineered (32)
      • engineered (35-36)
      • engineered (38)
      • engineered (44-45)
      • engineered (53-54)
      • engineered (61-62)
      • engineered (70)
      • engineered (72)
      • engineered (81)
      • engineered (83)
      • engineered (88-89)
      • engineered (92)
    Domains in SCOPe 2.06: d3ggub_
  • Heterogens: 017, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3gguA (A:)
pqitlwqrpivtvkiegqlkealldtgaddtvfeeltlsgrwkprliggiggfvrvrqyd
qvpieicghkvidtvlvgptptnvigrnvmtqlgctlnf

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3gguB (B:)
pqitlwqrpivtvkiegqlkealldtgaddtvfeeltlsgrwkprliggiggfvrvrqyd
qvpieicghkvidtvlvgptptnvigrnvmtqlgctlnf