PDB entry 3fqk

View 3fqk on RCSB PDB site
Description: Hepatitis C virus polymerase NS5B (BK 1-570) with HCV-796 inhibitor
Class: transferase
Keywords: hcv, hepatitis, ns5b, transferase, RNA-dependent RNA polymerase, hcv-796
Deposited on 2009-01-07, released 2009-02-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-07-07, with a file datestamp of 2009-07-02.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.212
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:11105]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.07: d3fqka1, d3fqka2
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:11105]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.07: d3fqkb1, d3fqkb2
  • Heterogens: 79Z, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fqkA (A:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3fqkA (A:)
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrl
dlsgwfvagysggdiyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3fqkB (B:)
mhhhhhhmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtf
drlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlssk
avnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekma
lydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendir
veesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntlt
cylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdpp
qpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniim
yaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafsl
hsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktkl
kltpipaasrldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3fqkB (B:)
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrl
dlsgwfvagysggdiyh