PDB entry 3dw8

View 3dw8 on RCSB PDB site
Description: Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit
Class: hydrolase/hydrolase inhibitor
Keywords: holoenzyme, B55, PR55, WD repeat, Hydrolase, Iron, Manganese, Metal-binding, Methylation, Phosphoprotein, Protein phosphatase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2008-07-21, released 2008-10-07
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.228
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30153 (1-581)
      • expression tag (0)
    Domains in SCOPe 2.02: d3dw8a_
  • Chain 'B':
    Compound: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63151
      • engineered (309)
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3dw8c_
  • Chain 'D':
    Compound: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30153 (1-581)
      • expression tag (0)
    Domains in SCOPe 2.02: d3dw8d_
  • Chain 'E':
    Compound: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63151
      • engineered (309)
  • Chain 'F':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3dw8f_
  • Chain 'G':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Chain 'H':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3dw8A (A:)
mslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3dw8C (C:)
mdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhg
qfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhes
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhi
raldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsra
hqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephv
trrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >3dw8C (C:)
ftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgqfhdl
melfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesrqitq
vygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhiraldr
lqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrahqlvm
egynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpap

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3dw8D (D:)
mslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3dw8F (F:)
mdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhg
qfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhes
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhi
raldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsra
hqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephv
trrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >3dw8F (F:)
ftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgqfhdl
melfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesrqitq
vygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhiraldr
lqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrahqlvm
egynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpap

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.