PDB entry 3dl9

View 3dl9 on RCSB PDB site
Description: Crystal structure of CYP2R1 in complex with 1-alpha-hydroxy-vitamin D2
Class: oxidoreductase
Keywords: cytochrome p450, vitamin d, vitamin s 25-hydroxylase, drug metabolism, Structural Genomics, Structural Genomics Consortium, SGC, Disease mutation, Endoplasmic reticulum, Heme, Iron, Membrane, Metal-binding, Microsome, Monooxygenase, Oxidoreductase
Deposited on 2008-06-26, released 2008-08-05
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.72 Å
R-factor: 0.184
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2R1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2R1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6VVX0 (Start-474)
      • expression tag (475)
    Domains in SCOPe 2.01: d3dl9a1
  • Chain 'B':
    Compound: Cytochrome P450 2R1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2R1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6VVX0 (Start-474)
      • expression tag (475-478)
    Domains in SCOPe 2.01: d3dl9b1
  • Heterogens: BCD, HEM, V2H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dl9A (A:)
makktkqrrpmgfppgppglpfigniyslaasselphvymrkqsqvygeifsldlggist
vvlngydvvkeclvhqseifadrpclplfmkmtkmggllnsrygrgwvdhrrlavnsfry
fgygqksfeskileetkffndaietykgrpfdfkqlitnavsnitnliifgerftyedtd
fqhmielfsenvelaasasvflynafpwigilpfgkhqqlfrnaavvydflsrliekasv
nrkpqlpqhfvdayldemdqgkndpsstfskenlifsvgeliiagtetttnvlrwailfm
alypniqgqvqkeidlimgpngkpswddkckmpyteavlhevlrfcnivplgifhatsed
avvrgysipkgttvitnlysvhfdekywrdpevfhperfldssgyfakkealvpfslgrr
hclgehlarmemflfftallqrfhlhfphelvpdlkprlgmtlqpqpylicaerrhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dl9A (A:)
gfppgppglpfigniyslaasselphvymrkqsqvygeifsldlggistvvlngydvvke
clvhqseifadrpclplfmkmtkmggllnsrygrgwvdhrrlavnsfryfgygqksfesk
ileetkffndaietykgrpfdfkqlitnavsnitnliifgerftyedtdfqhmielfsen
velaasasvflynafpwigilpfgkhqqlfrnaavvydflsrliekasvnrkpqlpqhfv
dayldemdqgkndpsstfskenlifsvgeliiagtetttnvlrwailfmalypniqgqvq
keidlimgpngkpswddkckmpyteavlhevlrfcnivplgifhatsedavvrgysipkg
ttvitnlysvhfdekywrdpevfhperfldssgyfakkealvpfslgrrhclgehlarme
mflfftallqrfhlhfphelvpdlkprlgmtlqpqpylicaerrh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dl9B (B:)
makktkqrrpmgfppgppglpfigniyslaasselphvymrkqsqvygeifsldlggist
vvlngydvvkeclvhqseifadrpclplfmkmtkmggllnsrygrgwvdhrrlavnsfry
fgygqksfeskileetkffndaietykgrpfdfkqlitnavsnitnliifgerftyedtd
fqhmielfsenvelaasasvflynafpwigilpfgkhqqlfrnaavvydflsrliekasv
nrkpqlpqhfvdayldemdqgkndpsstfskenlifsvgeliiagtetttnvlrwailfm
alypniqgqvqkeidlimgpngkpswddkckmpyteavlhevlrfcnivplgifhatsed
avvrgysipkgttvitnlysvhfdekywrdpevfhperfldssgyfakkealvpfslgrr
hclgehlarmemflfftallqrfhlhfphelvpdlkprlgmtlqpqpylicaerrhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dl9B (B:)
fppgppglpfigniyslaasselphvymrkqsqvygeifsldlggistvvlngydvvkec
lvhqseifadrpclplfmkmtkmggllnsrygrgwvdhrrlavnsfryfgygqksfeski
leetkffndaietykgrpfdfkqlitnavsnitnliifgerftyedtdfqhmielfsenv
elaasasvflynafpwigilpfgkhqqlfrnaavvydflsrliekasvnrkpqlpqhfvd
ayldemdqgkndpsstfskenlifsvgeliiagtetttnvlrwailfmalypniqgqvqk
eidlimgpngkpswddkckmpyteavlhevlrfcnivplgifhatsedavvrgysipkgt
tvitnlysvhfdekywrdpevfhperfldssgyfakkealvpfslgrrhclgehlarmem
flfftallqrfhlhfphelvpdlkprlgmtlqpqpylicaerrhhhh