PDB entry 3csi

View 3csi on RCSB PDB site
Description: Crystal Structure of the Glutathione Transferase Pi allelic variant*C, I104V/A113V, in complex with the Chlorambucil-Glutathione Conjugate
Class: transferase
Keywords: transferase, glutathione, detoxification, chlorambucil, allelic variant
Deposited on 2008-04-09, released 2008-07-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-03-21, with a file datestamp of 2012-03-16.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.169
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutathione S-transferase P
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTP1, FAEES3, GST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09211 (0-208)
      • engineered (103)
      • engineered (112)
    Domains in SCOPe 2.04: d3csia1, d3csia2
  • Chain 'B':
    Compound: Glutathione S-transferase P
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTP1, FAEES3, GST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09211 (0-208)
      • engineered (103)
      • engineered (112)
    Domains in SCOPe 2.04: d3csib1, d3csib2
  • Chain 'C':
    Compound: Glutathione S-transferase P
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTP1, FAEES3, GST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09211 (0-208)
      • engineered (103)
      • engineered (112)
    Domains in SCOPe 2.04: d3csic1, d3csic2
  • Chain 'D':
    Compound: Glutathione S-transferase P
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTP1, FAEES3, GST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09211 (0-208)
      • engineered (103)
      • engineered (112)
    Domains in SCOPe 2.04: d3csid1, d3csid2
  • Heterogens: CL, MES, LZ6, GSH, CO3, CA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3csiA (A:)
ppytvvyfpvrgrcaalrmlladqgqswkeevvtvetwqegslkasclygqlpkfqdgdl
tlyqsntilrhlgrtlglygkdqqeaalvdmvndgvedlrckyvsliytnyevgkddyvk
alpgqlkpfetllsqnqggktfivgdqisfadynlldlllihevlapgcldafpllsayv
grlsarpklkaflaspeyvnlpingngkq

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3csiB (B:)
ppytvvyfpvrgrcaalrmlladqgqswkeevvtvetwqegslkasclygqlpkfqdgdl
tlyqsntilrhlgrtlglygkdqqeaalvdmvndgvedlrckyvsliytnyevgkddyvk
alpgqlkpfetllsqnqggktfivgdqisfadynlldlllihevlapgcldafpllsayv
grlsarpklkaflaspeyvnlpingngkq

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3csiC (C:)
ppytvvyfpvrgrcaalrmlladqgqswkeevvtvetwqegslkasclygqlpkfqdgdl
tlyqsntilrhlgrtlglygkdqqeaalvdmvndgvedlrckyvsliytnyevgkddyvk
alpgqlkpfetllsqnqggktfivgdqisfadynlldlllihevlapgcldafpllsayv
grlsarpklkaflaspeyvnlpingngkq

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3csiD (D:)
ppytvvyfpvrgrcaalrmlladqgqswkeevvtvetwqegslkasclygqlpkfqdgdl
tlyqsntilrhlgrtlglygkdqqeaalvdmvndgvedlrckyvsliytnyevgkddyvk
alpgqlkpfetllsqnqggktfivgdqisfadynlldlllihevlapgcldafpllsayv
grlsarpklkaflaspeyvnlpingngkq