PDB entry 3c0a

View 3c0a on RCSB PDB site
Description: Lactobacillus CASEI Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 2
Class: transferase
Keywords: METHYLTRANSFERASE, STRUCTURE-BASED DRUG DESIGN, Nucleotide biosynthesis, TRANSFERASE
Deposited on 2008-01-19, released 2009-01-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-07-24, with a file datestamp of 2013-07-19.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.255
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Lactobacillus casei [TaxId:1582]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3c0aa_
  • Heterogens: UMP, 14C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c0aA (A:)
mleqpyldlakkvldeghfkpdrthtgtysifghqmrfdlskgfpllttkkvpfglikse
llwflhgdtnirfllqhrnhiwdewafekwvksdeyhgpdmtdfghrsqkdpefaavyhe
emakfddrvlhddafaakygdlglvygsqwrawhtskgdtidqlgdvieqikthpysrrl
ivsawnpedvptmalppchtlyqfyvndgklslqlyqrsadiflgvpfniasyallthlv
ahecglevgefihtfgdahlyvnhldqikeqlsrtprpaptlqlnpdkhdifdfdmkdik
llnydpypaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >3c0aA (A:)
mleqpyldlakkvldeghfkptgtysifghqmrfdlskgfpllttkkvpfgliksellwf
lhgdtnirfllqhrnhiwdewafekwvksdeyhyheemakfddrvlhddafaakygdlgl
vygsqwrawhtskgdtidqlgdvieqikthpysrrlivsawnpedvptmalppchtlyqf
yvndgklslqlyqrsadiflgvpfniasyallthlvahecglevgefihtfgdahlyvnh
ldqikeqlsrtprpaptlqlnpdkhdifdfdmkdikllnydpypaikap