PDB entry 3b7t

View 3b7t on RCSB PDB site
Description: [E296Q]LTA4H in complex with Arg-Ala-Arg substrate
Class: hydrolase
Keywords: transition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc, tripeptide substrate
Deposited on 2007-10-31, released 2008-09-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.206
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leukotriene A-4 hydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: LTA4H, LTA4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09960 (6-615)
      • engineered (301)
    Domains in SCOPe 2.06: d3b7ta1, d3b7ta2, d3b7ta3
  • Chain 'B':
    Compound: RAR peptide
  • Heterogens: ZN, YB, IMD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3b7tA (A:)
hhhhhhpeivdtcslaspasvcrtkhlhlrcsvdftrrtltgtaaltvqsqednlrslvl
dtkdltiekvvingqevkyalgerqsykgspmeislpialsknqeivieisfetspkssa
lqwltpeqtsgkehpylfsqcqaihcrailpcqdtpsvkltytaevsvpkelvalmsair
dgetpdpedpsrkiykfiqkvpipcylialvvgalesrqigprtlvwsekeqveksayef
setesmlkiaedlggpyvwgqydllvlppsfpyggmenpcltfvtptllagdkslsnvia
hqishswtgnlvtnktwdhfwlneghtvylerhicgrlfgekfrhfnalggwgelqnsvk
tfgethpftklvvdltdidpdvayssvpyekgfallfyleqllggpeiflgflkayvekf
syksittddwkdflysyfkdkvdvlnqvdwnawlyspglppikpnydmtltnacialsqr
witakeddlnsfnatdlkdlsshqlneflaqtlqraplplghikrmqevynfnainnsei
rfrwlrlciqskwedaiplalkmateqgrmkftrplfkdlaafdkshdqavrtyqehkas
mhpvtamlvgkdlkvd

    Sequence, based on observed residues (ATOM records): (download) 
    >3b7tA (A:)
peivdtcslaspasvcrtkhlhlrcsvdftrrtltgtaaltvqsqednlrslvldtkdlt
iekvvingqevkyalgerqsykgspmeislpialsknqeivieisfetspkssalqwltp
eqtsgkehpylfsqcqaihcrailpcqdtpsvkltytaevsvpkelvalmsairdgetpd
pedpsrkiykfiqkvpipcylialvvgalesrqigprtlvwsekeqveksayefsetesm
lkiaedlggpyvwgqydllvlppsfpyggmenpcltfvtptllagdkslsnviahqishs
wtgnlvtnktwdhfwlneghtvylerhicgrlfgekfrhfnalggwgelqnsvktfgeth
pftklvvdltdidpdvayssvpyekgfallfyleqllggpeiflgflkayvekfsyksit
tddwkdflysyfkdkvdvlnqvdwnawlyspglppikpnydmtltnacialsqrwitake
ddlnsfnatdlkdlsshqlneflaqtlqraplplghikrmqevynfnainnseirfrwlr
lciqskwedaiplalkmateqgrmkftrplfkdlaafdkshdqavrtyqehkasmhpvta
mlvgkdlkvd

  • Chain 'B':
    No sequence available.