PDB entry 2xyw
View 2xyw on RCSB PDB site
Description: novel sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (ppar) gamma-delta agonists with high potency and in-vivo efficacy
Class: transcription
Keywords: DNA-binding, transcription, transcription regulation, receptor, activator, zinc-finger
Deposited on
2010-11-19, released
2011-02-23
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-05-25, with a file datestamp of
2011-05-20.
Experiment type: XRAY
Resolution: 3.14 Å
R-factor: 0.1906
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Peroxisome proliferator-activated receptor delta
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2xywa_ - Chain 'B':
Compound: Peroxisome proliferator-activated receptor delta
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2xywb_ - Heterogens: 08S, BOG
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2xywA (A:)
mkkghhhhhhggsqynpqvadlkafskhiynaylknfnmtkkkarsiltgkashtapfvi
hdietlwqaekglvwkqlvnglppykeisvhvfyrcqcttvetvreltefaksipsfssl
flndqvtllkygvheaifamlasivnkdgllvangsgfvtreflrslrkpfsdiiepkfe
favkfnalelddsdlalfiaaiilcgdrpglmnvprveaiqdtilralefhlqanhpdaq
ylfpkllqkmadlrqlvtehaqmmqrikktetetslhpllqeiykdmy
Sequence, based on observed residues (ATOM records): (download)
>2xywA (A:)
dlkafskhiynaylknfnmtkkkarsiltgkapfvihdietlwqaekglvwkqlvnglpp
ykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasi
vnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiil
cgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmm
qrikktetetslhpllqeiykdm
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2xywB (B:)
mkkghhhhhhggsqynpqvadlkafskhiynaylknfnmtkkkarsiltgkashtapfvi
hdietlwqaekglvwkqlvnglppykeisvhvfyrcqcttvetvreltefaksipsfssl
flndqvtllkygvheaifamlasivnkdgllvangsgfvtreflrslrkpfsdiiepkfe
favkfnalelddsdlalfiaaiilcgdrpglmnvprveaiqdtilralefhlqanhpdaq
ylfpkllqkmadlrqlvtehaqmmqrikktetetslhpllqeiykdmy
Sequence, based on observed residues (ATOM records): (download)
>2xywB (B:)
dlkafskhiynaylknfnmtkkkarsiltgkapfvihdietlwqaekglvwkqlvnglpp
ykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasi
vnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiil
cgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmm
qrikktetetslhpllqeiykdm