PDB entry 2xnu

View 2xnu on RCSB PDB site
Description: acetylcholine binding protein (achbp) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
Class: receptor
Keywords: receptor, choline-binding protein, in-silico screening, ligand-gated ion channels, electrophysiology, cys-loop receptors
Deposited on 2010-08-06, released 2011-08-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.208
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • conflict (59)
      • conflict (154)
    Domains in SCOPe 2.05: d2xnua_
  • Chain 'B':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • conflict (59)
      • conflict (154)
    Domains in SCOPe 2.05: d2xnub_
  • Chain 'C':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • conflict (59)
      • conflict (154)
    Domains in SCOPe 2.05: d2xnuc_
  • Chain 'D':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • conflict (59)
      • conflict (154)
    Domains in SCOPe 2.05: d2xnud_
  • Chain 'E':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8
      • conflict (59)
      • conflict (154)
    Domains in SCOPe 2.05: d2xnue_
  • Heterogens: VU3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xnuA (A:)
mlvsvylallvacvgqahsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkv
dsstnevdlvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvls
pqiavvthdgsvmfipaqrlsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqv
dlssyyasskyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfd

    Sequence, based on observed residues (ATOM records): (download) 
    >2xnuA (A:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvyyeqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xnuB (B:)
mlvsvylallvacvgqahsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkv
dsstnevdlvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvls
pqiavvthdgsvmfipaqrlsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqv
dlssyyasskyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfd

    Sequence, based on observed residues (ATOM records): (download) 
    >2xnuB (B:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvyyeqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2xnuC (C:)
mlvsvylallvacvgqahsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkv
dsstnevdlvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvls
pqiavvthdgsvmfipaqrlsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqv
dlssyyasskyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfd

    Sequence, based on observed residues (ATOM records): (download) 
    >2xnuC (C:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvyyeqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrer

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2xnuD (D:)
mlvsvylallvacvgqahsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkv
dsstnevdlvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvls
pqiavvthdgsvmfipaqrlsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqv
dlssyyasskyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfd

    Sequence, based on observed residues (ATOM records): (download) 
    >2xnuD (D:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvyyeqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrerr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2xnuE (E:)
mlvsvylallvacvgqahsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkv
dsstnevdlvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvls
pqiavvthdgsvmfipaqrlsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqv
dlssyyasskyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfd

    Sequence, based on observed residues (ATOM records): (download) 
    >2xnuE (E:)
qanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkvdsstnevdlvyyeqqrwkl
nslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvmfipaqr
lsfmcdptgvdseegvtcavkfgswvysgfeidlktdtdqvdlssyyasskyeilsatqt
rqvqhysccpepyidvnlvvkfrerr