PDB entry 2xi2

View 2xi2 on RCSB PDB site
Description: hcv-h77 ns5b apo polymerase
Class: transferase
Keywords: transferase, nonstructural protein, replication, rdrp, de novo priming
Deposited on 2010-06-25, released 2010-08-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-03-30, with a file datestamp of 2011-03-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.1641
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27958 (0-End)
      • conflict (48)
      • engineered mutation (64)
      • conflict (91)
      • conflict (216)
      • conflict (282)
      • conflict (294)
      • conflict (504)
      • conflict (512)
      • conflict (516)
      • conflict (539)
      • conflict (64)
    Domains in SCOPe 2.07: d2xi2a_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27958 (0-End)
      • conflict (48)
      • engineered mutation (64)
      • conflict (91)
      • conflict (216)
      • conflict (282)
      • conflict (294)
      • conflict (504)
      • conflict (512)
      • conflict (516)
      • conflict (539)
      • conflict (64)
    Domains in SCOPe 2.07: d2xi2b_
  • Chain 'C':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27958 (0-End)
      • conflict (48)
      • engineered mutation (64)
      • conflict (91)
      • conflict (216)
      • conflict (282)
      • conflict (294)
      • conflict (504)
      • conflict (512)
      • conflict (516)
      • conflict (539)
      • conflict (64)
    Domains in SCOPe 2.07: d2xi2c_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2xi2A (A:)
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyhdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrldlsgwftagysggdiyhsvsharprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2xi2A (A:)
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyhdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrldlsgwftagysggdiyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2xi2B (B:)
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyhdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrldlsgwftagysggdiyhsvsharprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2xi2B (B:)
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyhdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrlgwftagysggdiyh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2xi2C (C:)
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyhdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrldlsgwftagysggdiyhsvsharprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2xi2C (C:)
smsyswtgalvtpcaaeeqklpinalsnsllrhhnlvysttsrsacqrqkkvtfdrlqvl
dshyhdvlkevkaaaskvkanllsveeacsltpphsakskfgygakdvrcharkavahin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klplavmgssygfqyspgqrveflvqawkskktpmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnsrgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqalnceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrarllsrggraaicgkylfnwavrtklkltpia
aagrllsgwftagysggdiyh