PDB entry 2wg3

View 2wg3 on RCSB PDB site
Description: crystal structure of the complex between human hedgehog-interacting protein hip and desert hedgehog without calcium
Class: signaling protein
Keywords: lipoprotein, development, membrane, secreted, protease, palmitate, hydrolase, developmental protein, autocatalytic cleavage, signal transduction, egf-like domain, disease mutation, hedgehog signaling, glycoprotein, cell membrane, disulfide bond, signaling protein
Deposited on 2009-04-15, released 2009-06-30
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.227
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: desert hedgehog protein n-product
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WG3 (156-End)
    • Uniprot O43323 (1-155)
    Domains in SCOPe 2.03: d2wg3a_
  • Chain 'B':
    Compound: desert hedgehog protein n-product
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WG3
    • Uniprot O43323 (1-End)
    Domains in SCOPe 2.03: d2wg3b_
  • Chain 'C':
    Compound: hedgehog-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: hedgehog-interacting protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, CL, PO4, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wg3A (A:)
alvpllykqfvpgvpertlgasgpaegrvargserfrdlvpnynpdiifkdeensgadrl
mterckervnalaiavmnmwpgvrlrvtegwdedghhaqdslhyegraldittsdrdrnk
ygllarlaveagfdwvyyesrnhvhvsvkadnslavlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wg3A (A:)
alvpllykqfvpgvpertlgasgpaegrvargserfrdlvpnynpdiifkgadrlmterc
kervnalaiavmnmwpgvrlrvtegwdedghhaqdslhyegraldittsdrdrnkyglla
rlaveagfdwvyyesrnhvhvsvkadnslavlehh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wg3B (B:)
alvpllykqfvpgvpertlgasgpaegrvargserfrdlvpnynpdiifkdeensgadrl
mterckervnalaiavmnmwpgvrlrvtegwdedghhaqdslhyegraldittsdrdrnk
ygllarlaveagfdwvyyesrnhvhvsvkadnslavlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wg3B (B:)
alvpllykqfvpgvpertlgasgpaegrvargserfrdlvpnynpdiifksgadrlmter
ckervnalaiavmnmwpgvrlrvtegwdedghhaqdslhyegraldittsdrdrnkygll
arlaveagfdwvyyesrnhvhvsvkadnsl

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.