PDB entry 2w12

View 2w12 on RCSB PDB site
Description: high-resolution crystal structure of the p-I snake venom metalloproteinase bap1 in complex with a peptidomimetic: insights into inhibitor binding
Class: hydrolase/inhibitor
Keywords: HYDROLASE INHIBITOR COMPLEX, METAL-BINDING, ZINC-DEPENDING, METALLOPROTEASE, METALLOPROTEINASE-INHIBITOR COMPLEX, TOXIN, SECRETED, PROTEASE, HYDROLASE, P-I SNAKE VENOM METALLOPROTEINASE, METZINCIN, CHEMOTAXIS, ADAMALYSIN, ENDOPEPTIDASE, ALPHA-BETA PROTEIN, MATRIXMETALLOPROTEINASE, TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME, PYRROLIDONE CARBOXYLIC ACID, HYDROLASE-INHIBITOR complex
Deposited on 2008-10-14, released 2009-06-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-09-21, with a file datestamp of 2011-09-16.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: 0.149
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: zinc metalloproteinase bap1
  Species: Bothrops asper [TaxId:8722]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P83512 (0-201)
  Domains in SCOPe 2.06: d2w12a_
• Heterogens: ZN, WR2, GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2w12A (A:)
  erfspryielavvadhgiftkynsnlntirtrvhemlntvngfyrsvdvhaplanlevws
  kqdlikvqkdssktlksfgewrerdllprishdhaqlltavvfdgntigraytggmcdpr
  hsvgvvrdhsknnlwvavtmahelghnlgihhdtgscscgakscimasvlskvlsyefsd
  csqnqyetyltnhnpqcilnkp