PDB entry 2vt0

View 2vt0 on RCSB PDB site
Description: x-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells
Class: hydrolase
Keywords: hydrolase, alternative initiation, sphingolipid metabolism, israel structural proteomics center, disease mutation, glucocerebrosidase, pharmaceutical, gaucher disease, lipid metabolism, glucosidase, glycosidase, polymorphism, glycoprotein, ispc, membrane, cerezyme, lysosome, structural genomics, alternative splicing
Deposited on 2008-05-03, released 2008-09-23
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.154
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VT0 (499-End)
      • conflict (56)
      • conflict (496)
    • Uniprot Q9BDT0 (2-498)
    Domains in SCOPe 2.01: d2vt0a1, d2vt0a2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VT0
      • conflict (56)
      • conflict (496)
    • Uniprot Q9BDT0 (2-End)
    Domains in SCOPe 2.01: d2vt0b1, d2vt0b2
  • Heterogens: CBU, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vt0A (A:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records): (download) 
    >2vt0A (A:)
efarpcipksfgyssvvcvcnatycdsfpalgtfsryestrsgrrmelsmgpiqanhtgt
gllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvpm
ascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtspt
wlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagllsg
ypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaak
yvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgmqy
shsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghf
skfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfleti
spgysihtylwhrql

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vt0B (B:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records): (download) 
    >2vt0B (B:)
arpcipksfgyssvvcvcnatycdsflgtfsryestrsgrrmelsmgpiqanhtgtglll
tlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvpmascd
fsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtsptwlkt
ngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagllsgypfq
clgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaakyvhg
iavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgmqyshsi
itnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghfskfi
pegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfletispgy
sihtylwhr