PDB entry 2v8q

View 2v8q on RCSB PDB site
Description: crystal structure of the regulatory fragment of mammalian ampk in complexes with amp
Class: transferase
Keywords: phosphorylation, nucleotide-binding, serine/threonine-protein kinase, kinase, magnesium, cbs domain, transferase
Deposited on 2007-08-13, released 2007-09-25
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.213
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-amp-activated protein kinase catalytic subunit alpha-1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V8Q (Start-3)
    • Uniprot P54645 (4-156)
    Domains in SCOPe 2.05: d2v8qa1
  • Chain 'B':
    Compound: 5'-amp-activated protein kinase subunit beta-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2V8Q
    • Uniprot O43741 (Start-86)
    Domains in SCOPe 2.05: d2v8qb1
  • Chain 'E':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2v8qe1, d2v8qe2
  • Heterogens: AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2v8qA (A:)
gsmawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrknpvtstfskmslql
yqvdsrtylldfrsiddeiteaksgtatpqrsgsisnyrscqrsdsdaeaqgkpsevslt
ssvtsldsspvdvaprpgshtieffemcanlikilaq

    Sequence, based on observed residues (ATOM records): (download) 
    >2v8qA (A:)
smawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrknpvtstfskmslqly
qvdsrtylldfrsiddevaprpgshtieffemcanlikilaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2v8qB (B:)
mgpygqemyafrseerfksppilpphllqvilnkdtniscdpallpepnhvmlnhlyals
ikdsvmvlsathrykkkyvttllykpi

    Sequence, based on observed residues (ATOM records): (download) 
    >2v8qB (B:)
gqemyafrseerfksppilpphllqvilnkdtnpnhvmlnhlyalsikdsvmvlsathry
kkkyvttllykpi

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2v8qE (E:)
mesvaaesapapenehsqetpesnssvyttfmkshrcydliptssklvvfdtslqvkkaf
falvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkietwrevy
lqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkflklfit
efpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiy
skfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetleaiinrlveaevhrlv
vvdehdvvkgivslsdilqalvltggekkp

    Sequence, based on observed residues (ATOM records): (download) 
    >2v8qE (E:)
snssvyttfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfv
gmltitdfinilhryyksalvqiyeleehkietwrevylqdsfkplvcispnaslfdavs
slirnkihrlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyan
iamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvt
kalqhrshyfegvlkcylhetleaiinrlveaevhrlvvvdehdvvkgivslsdilqalv
ltgg