PDB entry 2uw9

View 2uw9 on RCSB PDB site
Description: structure of pkb-beta (akt2) complexed with 4-(4-chloro-phenyl)-4-(4-(1h-pyrazol-4-yl)-phenyl)-piperidine
Class: transferase/inhibitor
Keywords: transferase/inhibitor, transferase/inhibitor complex, wnt signaling pathway, serine/threonine-protein kinase, kinase, transferase, ATP-binding, phosphorylation, nucleotide-binding, alternative splicing
Deposited on 2007-03-19, released 2007-05-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.226
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: rac-beta serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2UW9 (Start-341)
    • Uniprot P31751 (5-End)
    Domains in SCOPe 2.06: d2uw9a_
  • Chain 'C':
    Compound: Glycogen synthase kinase-3 beta
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GVP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2uw9A (A:)
gamdpkvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvte
srvlqntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeiv
saleylhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylape
vledndygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksl
lagllkkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfd
deftaqsititppdrydslglleldqreeqemfedfdyiadw

    Sequence, based on observed residues (ATOM records): (download) 
    >2uw9A (A:)
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsitqemfedfdyiadw

  • Chain 'C':
    No sequence available.