PDB entry 2tsr

View 2tsr on RCSB PDB site
Description: thymidylate synthase from rat in ternary complex with dump and tomudex
Class: methyltransferase
Keywords: thymidylate synthase, methyltransferase, dump, tomudex, antifolate
Deposited on 1998-06-19, released 1999-02-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-10, with a file datestamp of 2012-10-05.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.162
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2tsra_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2tsrb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2tsrc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2tsrd_
  • Heterogens: UMP, D16, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2tsrA (A:)
mlvegselqsgaqqprteapqhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgadykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklrilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >2tsrA (A:)
qhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgady
kdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvng
elscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplk
iqlqreprpfpklrilrkvetiddfkvedfqiegynphpti

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2tsrB (B:)
mlvegselqsgaqqprteapqhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgadykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklrilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >2tsrB (B:)
qhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgady
kdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvng
elscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplk
iqlqreprpfpklrilrkvetiddfkvedfqiegynphpti

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2tsrC (C:)
mlvegselqsgaqqprteapqhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgadykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklrilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >2tsrC (C:)
qhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgady
kdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvng
elscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplk
iqlqreprpfpklrilrkvetiddfkvedfqiegynphpti

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2tsrD (D:)
mlvegselqsgaqqprteapqhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgadykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklrilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >2tsrD (D:)
qhgelqylrqvehimrcgfkkedrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgpvygfqwrhfgady
kdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalppchalcqfyvvng
elscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlgdahiylnhieplk
iqlqreprpfpklrilrkvetiddfkvedfqiegynphpti