PDB entry 2npa

View 2npa on RCSB PDB site
Description: the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid
Class: transcription
Keywords: protein-agonist complex, TRANSCRIPTION
Deposited on 2006-10-26, released 2007-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07869 (0-End)
      • conflict (33)
    Domains in SCOPe 2.08: d2npaa_
  • Chain 'B':
    Compound: SRC- peptide from Nuclear receptor coactivator 1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Peroxisome proliferator-activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07869 (0-269)
      • conflict (33)
    Domains in SCOPe 2.08: d2npac_
  • Chain 'D':
    Compound: SRC- peptide from Nuclear receptor coactivator 1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MMB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2npaA (A:)
etadlkslakriyeaylknfnmnkvkarvilsgaasnnppfvihdmetlcmaektlvakl
vangiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaif
amlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislf
vaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvt
ehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >2npaA (A:)
etadlkslakriyeaylknfnmnkvkarvilsgaasnnppfvihdmetlcmaektlvakl
vangiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaif
amlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislf
vaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvt
ehaqlvqiikktesdaalhpllqeiyrdm

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2npaC (C:)
etadlkslakriyeaylknfnmnkvkarvilsgaasnnppfvihdmetlcmaektlvakl
vangiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaif
amlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislf
vaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvt
ehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >2npaC (C:)
etadlkslakriyeaylknfnmnkvkarvilsgaasnnppfvihdmetlcmaektlvakl
viqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifaml
ssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaa
iiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvteha
qlvqiikktesdaalhpllqeiyrdmy

  • Chain 'D':
    No sequence available.