PDB entry 2iwz

View 2iwz on RCSB PDB site
Description: human mitochondrial beta-ketoacyl acp synthase complexed with hexanoic acid
Class: transferase
Keywords: mitochondria, mitochondrion, lipid synthesis, fatty acid synthesis, fatty acid biosynthesis, beta-ketoacyl acp synthase, transit peptide, acyltransferase, claisen condensation, kas, cerulenin, transferase, homo sapiens
Deposited on 2006-07-05, released 2007-02-06
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: 0.156
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxoacyl-[acyl-carrier-protein] synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IWZ (Start-15)
    • Uniprot Q9NWU1 (16-437)
    Domains in SCOPe 2.04: d2iwza1, d2iwza2
  • Chain 'B':
    Compound: 3-oxoacyl-[acyl-carrier-protein] synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IWZ (Start-15)
    • Uniprot Q9NWU1 (16-437)
    Domains in SCOPe 2.04: d2iwzb1, d2iwzb2
  • Heterogens: 6NA, NH4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2iwzA (A:)
mrgshhhhhhgsiegrsrlhrrvvitgiglvtplgvgthlvwdrliggesgivslvgeey
ksipcsvaayvprgsdegqfneqnfvsksdiksmssptimaigaaelamkdsgwhpqsea
dqvatgvaigmgmiplevvsetalnfqtkgynkvspffvpkilvnmaagqvsiryklkgp
nhavstacttgahavgdsfrfiahgdadvmvaggtdscisplslagfsraralstnsdpk
lacrpfhpkrdgfvmgegaavlvleeyehavqrrariyaevlgyglsgdaghitapdpeg
egalrcmaaalkdagvqpeeisyinahatstplgdaaenkaikhlfkdhayalavsstkg
atghllgaagaveaafttlacyyqklpptlnldcsepefdlnyvplkaqewktekrfigl
tnsfgfggtnatlciagl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iwzA (A:)
iegrsrlhrrvvitgiglvtplgvgthlvwdrliggesgivslvgeeyksipcsvaayvp
rgsdegqfneqnfvsksdiksmssptimaigaaelamkdsgwhpqseadqvatgvaigmg
miplevvsetalnfqtkgynkvspffvpkilvnmaagqvsiryklkgpnhavstacttga
havgdsfrfiahgdadvmvaggtdscisplslagfsraralstnsdpklacrpfhpkrdg
fvmgegaavlvleeyehavqrrariyaevlgyglsgdaghitapdpegegalrcmaaalk
dagvqpeeisyinahatstplgdaaenkaikhlfkdhayalavsstkgatghllgaagav
eaafttlacyyqklpptlnldcsepefdlnyvplkaqewktekrfigltnsfgfggtnat
lciagl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iwzB (B:)
mrgshhhhhhgsiegrsrlhrrvvitgiglvtplgvgthlvwdrliggesgivslvgeey
ksipcsvaayvprgsdegqfneqnfvsksdiksmssptimaigaaelamkdsgwhpqsea
dqvatgvaigmgmiplevvsetalnfqtkgynkvspffvpkilvnmaagqvsiryklkgp
nhavstacttgahavgdsfrfiahgdadvmvaggtdscisplslagfsraralstnsdpk
lacrpfhpkrdgfvmgegaavlvleeyehavqrrariyaevlgyglsgdaghitapdpeg
egalrcmaaalkdagvqpeeisyinahatstplgdaaenkaikhlfkdhayalavsstkg
atghllgaagaveaafttlacyyqklpptlnldcsepefdlnyvplkaqewktekrfigl
tnsfgfggtnatlciagl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iwzB (B:)
iegrsrlhrrvvitgiglvtplgvgthlvwdrliggesgivslvgeeyksipcsvaayvp
rgsdegqfneqnfvsksdiksmssptimaigaaelamkdsgwhpqseadqvatgvaigmg
miplevvsetalnfqtkgynkvspffvpkilvnmaagqvsiryklkgpnhavstacttga
havgdsfrfiahgdadvmvaggtdscisplslagfsraralstnsdpklacrpfhpkrdg
fvmgegaavlvleeyehavqrrariyaevlgyglsgdaghitapdpegegalrcmaaalk
dagvqpeeisyinahatstplgdaaenkaikhlfkdhayalavsstkgatghllgaagav
eaafttlacyyqklpptlnldcsepefdlnyvplkaqewktekrfigltnsfgfggtnat
lciagl