PDB entry 2ieo

View 2ieo on RCSB PDB site
Description: Crystal structure analysis of HIV-1 protease mutant I84V with a potent non-peptide inhibitor (UIC-94017)
Class: hydrolase
Keywords: HIV-1 protease, mutant, I84V, dimer, inhibitor, UIC-94017, TMC114, darunavir, HYDROLASE
Deposited on 2006-09-19, released 2006-10-03
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.53 Å
R-factor: 0.146
AEROSPACI score: 0.66 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: GAG, POL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03368
    • engineered (6)
    • engineered (32)
    • engineered (62)
    • engineered (66)
    • engineered (83)
    • engineered (94)
  Domains in SCOPe 2.02: d2ieoa_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: GAG, POL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03368 (0-98)
    • engineered (6)
    • engineered (32)
    • engineered (62)
    • engineered (66)
    • engineered (83)
    • engineered (94)
  Domains in SCOPe 2.02: d2ieob_
• Heterogens: CL, NA, 017, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2ieoA (A:)
  pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvlvgptpvnvigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2ieoB (B:)
  pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvlvgptpvnvigrnlltqigatlnf