PDB entry 2iaj

View 2iaj on RCSB PDB site
Description: Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
Class: Transferase
Keywords: RT, NNRTI, NONNUCLEOSIDE INHIBITOR, DRUG RESISTANCE, DNA POLYMERIZATION, HIV, AIDS, DRUG DESIGN, Transferase
Deposited on 2006-09-08, released 2006-12-19
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.233
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H (p66 RT)
    Species: Human immunodeficiency virus type 1 BH10 [TaxId:11678]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (0-End)
      • engineered (102)
      • engineered (180)
      • engineered (279)
  • Chain 'B':
    Compound: Reverse transcriptase/ribonuclease H; p51 RT
    Species: Human immunodeficiency virus type 1 BH10 [TaxId:11678]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (0-End)
      • engineered (102)
      • engineered (180)
      • engineered (279)
    Domains in SCOPe 2.02: d2iajb_
  • Heterogens: MN, NA, ATP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iajB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
cqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaan

    Sequence, based on observed residues (ATOM records): (download) 
    >2iajB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
cqymddlyvgsdleigqhrtkieelrqhllrwglttpdkyelhpdkwtvqpivlpekdsw
tvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilke
pvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteav
qkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwy