SCOPe 2.08: Structural Classification of Proteins

PDB entry 2dhh

View 2dhh on RCSB PDB site
Description: Crystal structure of a multidrug transporter reveal a functionally rotating mechanism
Class: membrane protein
Keywords: membrane transporter, membrane protein, multidrug efflux, drug resistance, transporter, exporter, antiporter
Deposited on 2006-03-23, released 2006-08-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.27
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: AcrB
Species: Escherichia coli [TaxId:562]
Database cross-references and differences (RAF-indexed):
- Uniprot P31224 (0-End)
Domains in SCOPe 2.08: d2dhha1, d2dhha2, d2dhha3, d2dhha4, d2dhha5, d2dhha6, d2dhha7, d2dhha8
Chain 'B':
Compound: AcrB
Species: Escherichia coli [TaxId:562]
Database cross-references and differences (RAF-indexed):
- Uniprot P31224 (0-End)
Domains in SCOPe 2.08: d2dhhb1, d2dhhb2, d2dhhb3, d2dhhb4, d2dhhb5, d2dhhb6, d2dhhb7, d2dhhb8
Chain 'C':
Compound: AcrB
Species: Escherichia coli [TaxId:562]
Database cross-references and differences (RAF-indexed):
- Uniprot P31224 (0-End)
Domains in SCOPe 2.08: d2dhhc1, d2dhhc2, d2dhhc3, d2dhhc4, d2dhhc5, d2dhhc6, d2dhhc7, d2dhhc8
Heterogens: HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2dhhA (A:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2dhhA (A:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkfgwfnrmfeksthhytdsvggilrstgrylvlyliivvgmay
lfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyyltkeknnvesvfavng
fgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikdamvfafnlpaivel
gtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpngledtpqfkididqe
kaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyrmlpddigdwyvraa
dgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgeamelmeqlasklptg
vgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfsvmlvvplgvigall
aatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkglieatldavrmrlrp
ilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaiffvpvffvvvrrrfs
rk

Chain 'B':
Sequence, based on SEQRES records: (download)

>2dhhB (B:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2dhhB (B:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkfgwfnrmfeksthhytdsvggilrstgrylvlyliivvgmay
lfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyyltkeknnvesvfavng
fgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikdamvfafnlpaivel
gtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpngledtpqfkididqe
kaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyrmlpddigdwyvraa
dgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgeamelmeqlasklptg
vgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfsvmlvvplgvigall
aatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkglieatldavrmrlrp
ilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaiffvpvffvvvrrrfs
rk

Chain 'C':
Sequence, based on SEQRES records: (download)

>2dhhC (C:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkpiakgdhgegkkgffgwfnrmfeksthhytdsvggilrstgr
ylvlyliivvgmaylfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyylt
keknnvesvfavngfgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikd
amvfafnlpaivelgtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpng
ledtpqfkididqekaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyr
mlpddigdwyvraadgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgea
melmeqlasklptgvgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfs
vmlvvplgvigallaatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkgl
ieatldavrmrlrpilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaif
fvpvffvvvrrrfsrknediehshtvdhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2dhhC (C:)
mpnffidrpifawviaiiimlagglailklpvaqyptiappavtisasypgadaktvqdt
vtqvieqnmngidnlmymssnsdstgtvqitltfesgtdadiaqvqvqnklqlampllpq
evqqqgvsvekssssflmvvgvintdgtmtqedisdyvaanmkdaisrtsgvgdvqlfgs
qyamriwmnpnelnkfqltpvdvitaikaqnaqvaagqlggtppvkgqqlnasiiaqtrl
tsteefgkillkvnqdgsrvllrdvakielggenydiiaefngqpasglgiklatganal
dtaaairaelakmepffpsglkivypydttpfvkisihevvktlveaiilvflvmylflq
nfratliptiavpvvllgtfavlaafgfsintltmfgmvlaigllvddaivvvenvervm
aeeglppkeatrksmgqiqgalvgiamvlsavfvpmaffggstgaiyrqfsitivsamal
svlvaliltpalcatmlkfgwfnrmfeksthhytdsvggilrstgrylvlyliivvgmay
lfvrlpssflpdedqgvfmtmvqlpagatqertqkvlnevthyyltkeknnvesvfavng
fgfagrgqntgiafvslkdwadrpgeenkveaitmratrafsqikdamvfafnlpaivel
gtatgfdfelidqaglghekltqarnqllaeaakhpdmltsvrpngledtpqfkididqe
kaqalgvsindinttlgaawggsyvndfidrgrvkkvyvmseakyrmlpddigdwyvraa
dgqmvpfsafsssrweygsprlerynglpsmeilgqaapgkstgeamelmeqlasklptg
vgydwtgmsyqerlsgnqapslyaislivvflclaalyeswsipfsvmlvvplgvigall
aatfrgltndvyfqvgllttiglsaknailivefakdlmdkegkglieatldavrmrlrp
ilmtslafilgvmplvistgagsgaqnavgtgvmggmvtatvlaiffvpvffvvvrrrfs
rk