PDB entry 2c2y

View 2c2y on RCSB PDB site
Description: three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from mycobacterium tuberculosis
Class: oxidoreductase
Keywords: tetrahydrofolate, methylenetetrahydrofolate dehydrogenase, cyclohydrolase, hydrolase, oxidoreductase, psi, protein structure initiative, tb structural genomics consortium, tbsgc
Deposited on 2005-09-30, released 2005-10-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.194
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2C2Y
    • Uniprot O50385 (1-280)
    Domains in SCOPe 2.06: d2c2ya1, d2c2ya2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c2yA (A:)
vgaimldgkatrdeifgdlkqrvaaldaagrtpglgtilvgddpgsqayvrgkhadcakv
gitsirrdlpadistatlnetidelnanpdctgyivqlplpkhldenaalervdpakdad
glhptnlgrlvlgtpaplpctprgivhllrrydisiagahvvvigrgvtvgrplgllltr
rsenatvtlchtgtrdlpaltrqadivvaavgvahlltadmvrpgaavidvgvsrtddgl
vgdvhpdvwelaghvspnpggvgpltraflltnvvelaerr

    Sequence, based on observed residues (ATOM records): (download) 
    >2c2yA (A:)
gaimldgkatrdeifgdlkqrvaaldaagrtpglgtilvgddpgsqayvrgkhadcakvg
itsirrdlpadistatlnetidelnanpdctgyivqlplpkhldenaalervdpakdadg
lhptnlgrlvlgtpaplpctprgivhllrrydisiagahvvvigrgvtvgrplgllltrr
senatvtlchtgtrdlpaltrqadivvaavgvahlltadmvrpgaavidvgvsrtddglv
gdvhpdvwelaghvspnpggvgpltraflltnvvelaerr