PDB entry 2brl

View 2brl on RCSB PDB site
Description: crystal structure of hepatitis c virus polymerase in complex with an allosteric inhibitor (compound 2)
Class: transferase
Keywords: transferase, hepatitis c virus, hcv, ns5b, polymerase, RNA-dependent RNA- polymerase, allosteric inhibitor, nucleotidyltransferase
Deposited on 2005-05-06, released 2005-06-14
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.193
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2brla_
  • Heterogens: MN, POO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2brlA (A:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkl

    Sequence, based on observed residues (ATOM records): (download) 
    >2brlA (A:)
smsytwtgalitpcaaeesklmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkak
astvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpi
dttimaknevfcvgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgq
rveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslter
lyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngdd
lvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgk
rvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeql
ekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrv
wrhrarsvrarllsqggraatcgkylfnwavk