PDB entry 2bbt

View 2bbt on RCSB PDB site
Description: Human deltaF508 NBD1 with two solublizing mutations.
Class: transport protein
Keywords: ATP Binding Cassette, TRANSPORT PROTEIN
Deposited on 2005-10-17, released 2005-11-01
The last revision prior to the SCOPe 2.05 freeze date was dated 2010-02-16, with a file datestamp of 2010-02-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.235
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569
      • engineered (106)
      • engineered (248)
    Domains in SCOPe 2.05: d2bbta_
  • Chain 'B':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (1-End)
      • engineered (106)
      • engineered (248)
    Domains in SCOPe 2.05: d2bbtb_
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bbtA (A:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslffsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqnswimpgtikenii
gvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdadl
ylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfyg
tfselqnlrpdfssklmgcdsfdqfsaerrnsiltetlhrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >2bbtA (A:)
tevvmenvtafweegfgelfekakgtpvlkdinfkiergqllavagstgagktsllmmim
gelepsegkikhsgrisfcsqnswimpgtikeniigvsydeyryrsvikacqleediskf
aekdnivlggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklm
anktrilvtskmehlkkadkililhegssyfygtfselqnlrpdfssdsfdqfsaerrns
iltetlhrf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bbtB (B:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslffsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqnswimpgtikenii
gvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdadl
ylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfyg
tfselqnlrpdfssklmgcdsfdqfsaerrnsiltetlhrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >2bbtB (B:)
ttevvmenvtafweegfgelfekakqnnnntpvlkdinfkiergqllavagstgagktsl
lmmimgelepsegkikhsgrisfcsqnswimpgtikeniigvsydeyryrsvikacqlee
diskfaekdnivlgitlsggqrarislaravykdadlylldspfgyldvltekeifescv
cklmanktrilvtskmehlkkadkililhegssyfygtfselqnlrpdfssklmdsfdqf
saerrnsiltetlhrfsl