PDB entry 2aec

View 2aec on RCSB PDB site
Description: Crystal Structure of Human M340H-Beta1,4-Galactosyltransferase-I (M340H-B4GAL-T1) in Complex with GlcNAc-beta1,2-Man-alpha1,6-Man-beta-OR
Class: transferase
Keywords: beta1,4-Galactosyltransferase-I; Trisaccharide; Closed conformation; Mutant, TRANSFERASE
Deposited on 2005-07-22, released 2005-10-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.208
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-1,4-galactosyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: B4GALT1, GGTB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15291 (Start-286)
      • engineered (225-226)
      • engineered (228)
    Domains in SCOPe 2.06: d2aeca_
  • Chain 'B':
    Compound: Beta-1,4-galactosyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: B4GALT1, GGTB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15291 (Start-286)
      • engineered (225-226)
      • engineered (228)
    Domains in SCOPe 2.06: d2aecb_
  • Chain 'C':
    Compound: Beta-1,4-galactosyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: B4GALT1, GGTB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15291 (Start-286)
      • engineered (225-226)
      • engineered (228)
    Domains in SCOPe 2.06: d2aecc_
  • Heterogens: MN, SO4, UDH, DIO, MES, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aecA (A:)
asmtggqqmgrgsaslpacpeespllvgpmliefnmpvdlelvakqnpnvkmggryaprd
cvsphkvaiiipfrnrqehlkywlyylhpvlqrqqldygiyvinqagdtifnrakllnvg
fqealkdydytcfvfsdvdlipmndhnayrcfsqprhisvamdkfgfslpyvqyfggvsa
lskqqfltingfpnnywgwggedddifnrlvfrgmsisrpnavvgttrhirhsrdkknep
npqrfdriahtketmlsdglnsltyqvldvqryplytqitvdigtps

    Sequence, based on observed residues (ATOM records): (download) 
    >2aecA (A:)
lpacpeespllvgpmliefnmpvdlelvakqnpnvkmggryaprdcvsphkvaiiipfrn
rqehlkywlyylhpvlqrqqldygiyvinqagdtifnrakllnvgfqealkdydytcfvf
sdvdlipmndhnayrcfsqprhisvamdkfgfslpyvqyfggvsalskqqfltingfpnn
ywgwggedddifnrlvfrgmsisrpnavvgttrhirhsrdkknepnpqrfdriahtketm
lsdglnsltyqvldvqryplytqitvdigtps

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aecB (B:)
asmtggqqmgrgsaslpacpeespllvgpmliefnmpvdlelvakqnpnvkmggryaprd
cvsphkvaiiipfrnrqehlkywlyylhpvlqrqqldygiyvinqagdtifnrakllnvg
fqealkdydytcfvfsdvdlipmndhnayrcfsqprhisvamdkfgfslpyvqyfggvsa
lskqqfltingfpnnywgwggedddifnrlvfrgmsisrpnavvgttrhirhsrdkknep
npqrfdriahtketmlsdglnsltyqvldvqryplytqitvdigtps

    Sequence, based on observed residues (ATOM records): (download) 
    >2aecB (B:)
lpacpeespllvgpmliefnmpvdlelvakqnpnvkmggryaprdcvsphkvaiiipfrn
rqehlkywlyylhpvlqrqqldygiyvinqagdtifnrakllnvgfqealkdydytcfvf
sdvdlipmndhnayrcfsqprhisvamdkfgfslpyvqyfggvsalskqqfltingfpnn
ywgwggedddifnrlvfrgmsisrpnavvgttrhirhsrdkknepnpqrfdriahtketm
lsdglnsltyqvldvqryplytqitvdigtps

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2aecC (C:)
asmtggqqmgrgsaslpacpeespllvgpmliefnmpvdlelvakqnpnvkmggryaprd
cvsphkvaiiipfrnrqehlkywlyylhpvlqrqqldygiyvinqagdtifnrakllnvg
fqealkdydytcfvfsdvdlipmndhnayrcfsqprhisvamdkfgfslpyvqyfggvsa
lskqqfltingfpnnywgwggedddifnrlvfrgmsisrpnavvgttrhirhsrdkknep
npqrfdriahtketmlsdglnsltyqvldvqryplytqitvdigtps

    Sequence, based on observed residues (ATOM records): (download) 
    >2aecC (C:)
lpacpeespllvgpmliefnmpvdlelvakqnpnvkmggryaprdcvsphkvaiiipfrn
rqehlkywlyylhpvlqrqqldygiyvinqagdtifnrakllnvgfqealkdydytcfvf
sdvdlipmndhnayrcfsqprhisvamdkfgfslpyvqyfggvsalskqqfltingfpnn
ywgwggedddifnrlvfrgmsisrpnavvgttrhirhsrdkknepnpqrfdriahtketm
lsdglnsltyqvldvqryplytqitvdigtps