PDB entry 1waw

View 1waw on RCSB PDB site
Description: specificity and affinity of natural product cyclopentapeptide inhibitor argadin against human chitinase
Class: hydrolase/hydrolase inhibitor
Keywords: human chitinase, argadin, cyclopentapeptide inhibitors, chitinase inhibitors, glycosidase, hydrolase-hydrolase inhibitor complex
Deposited on 2004-10-28, released 2005-01-28
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-21.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.174
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: chitotriosidase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1wawa1, d1wawa2
  • Chain 'B':
    Compound: argadin
    Database cross-references and differences (RAF-indexed):
    • PDB 1WAW (0-4)
  • Heterogens: GOL, IPA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wawA (A:)
aklvcyftnwaqyrqgearflpkdldpslcthliyafagmtnhqlsttewndetlyqefn
glkkmnpklktllaiggwnfgtqkftdmvatannrqtfvnsairflrkysfdgldldwey
pgsqgspavdkerfttlvqdlanafqqeaqtsgkerlllsaavpagqtyvdagyevdkia
qnldfvnlmaydfhgswekvtghnsplykrqeesgaaaslnvdaavqqwlqkgtpaskli
lgmptygrsftlasssdtrvgapatgsgtpgpftkeggmlayyevcswkgatkqriqdqk
vpyifrdnqwvgfddvesfktkvsylkqkglggamvwaldlddfagfscnqgrypliqtl
rqelslpylpsgtpelevpkpgqpsepehgpspgqdtfcqgkadglypnprerssfysca
agrlfqqscptglvfsnsckcctwn

    Sequence, based on observed residues (ATOM records): (download) 
    >1wawA (A:)
aklvcyftnwaqyrqgearflpkdldpslcthliyafagmtnhqlsttewndetlyqefn
glkkmnpklktllaiggwnfgtqkftdmvatannrqtfvnsairflrkysfdgldldwey
pgsqgspavdkerfttlvqdlanafqqeaqtsgkerlllsaavpagqtyvdagyevdkia
qnldfvnlmaydfhgswekvtghnsplykrqeesgaaaslnvdaavqqwlqkgtpaskli
lgmptygrsftlasssdtrvgapatgsgtpgpftkeggmlayyevcswkgatkqriqdqk
vpyifrdnqwvgfddvesfktkvsylkqkglggamvwaldlddfagfscnqgrypliqtl
rqelsl

  • Chain 'B':
    No sequence available.