PDB entry 1szr

View 1szr on RCSB PDB site
Description: A Dimer interface mutant of ornithine decarboxylase reveals structure of gem diamine intermediate
Class: lyase
Keywords: pyridoxal phosphate, PXP, ODC, ornithine decarboxylase, Lyase, gem-diamine, carbinolamine, dimer interface, beta-alpha-barrels, greek key
Deposited on 2004-04-06, released 2004-10-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.244
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ornithine decarboxylase
    Species: Trypanosoma brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07805
      • engineered (293)
    Domains in SCOPe 2.08: d1szra1, d1szra2
  • Chain 'B':
    Compound: ornithine decarboxylase
    Species: Trypanosoma brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07805
      • engineered (293)
    Domains in SCOPe 2.08: d1szrb1, d1szrb2
  • Chain 'C':
    Compound: ornithine decarboxylase
    Species: Trypanosoma brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07805
      • engineered (293)
    Domains in SCOPe 2.08: d1szrc1, d1szrc2
  • Chain 'D':
    Compound: ornithine decarboxylase
    Species: Trypanosoma brucei [TaxId:5702]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07805
      • engineered (293)
    Domains in SCOPe 2.08: d1szrd1, d1szrd2
  • Heterogens: PXP, PLG, ORX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1szrA (A:)
gamdivvnddlscrflegfntrdalckkismntcdegdpffvadlgdivrkhetwkkclp
rvtpfyavkcnddwrvlgtlaalgtgfdcasnteiqrvrgigvppekiiyanpckqishi
ryardsgvdvmtfdcvdelekvakthpkakmvlristddslarcrlsvkfgakvedcrfi
leqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelgfnmhildigggfpg
trdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftlavnviakavtpgvq
tdvgahaesnaqsfmyyvndgvygsfncilydhavvrplpqrepipneklypssvwgptc
dgldqiveryylpemqvgewllfedmgaytvvgtssfngfqsptiyyvvsglpdhvvrel
ksqks

    Sequence, based on observed residues (ATOM records): (download) 
    >1szrA (A:)
gdpffvadlgdivrkhetwkkclprvtpfyavkcnddwrvlgtlaalgtgfdcasnteiq
rvrgigvppekiiyanpckqishiryardsgvdvmtfdcvdelekvakthpkakmvlris
tgakvedcrfileqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelgfnm
hildigggfpgtrdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftlavn
viakavtqsfmyyvndgvygsfncilydhavvrplpqrepipneklypssvwgptcdgld
qiveryylpemqvgewllfedmgaytvvgtssfngfqsptiyyvv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1szrB (B:)
gamdivvnddlscrflegfntrdalckkismntcdegdpffvadlgdivrkhetwkkclp
rvtpfyavkcnddwrvlgtlaalgtgfdcasnteiqrvrgigvppekiiyanpckqishi
ryardsgvdvmtfdcvdelekvakthpkakmvlristddslarcrlsvkfgakvedcrfi
leqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelgfnmhildigggfpg
trdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftlavnviakavtpgvq
tdvgahaesnaqsfmyyvndgvygsfncilydhavvrplpqrepipneklypssvwgptc
dgldqiveryylpemqvgewllfedmgaytvvgtssfngfqsptiyyvvsglpdhvvrel
ksqks

    Sequence, based on observed residues (ATOM records): (download) 
    >1szrB (B:)
gdpffvadlgdivrkhetwkkclprvtpfyavkcnddwrvlgtlaalgtgfdcasnteiq
rvrgigvppekiiyanpckqishiryardsgvdvmtfdcvdelekvakthpkakmvlris
tkfgakvedcrfileqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelgf
nmhildigggfpgtrdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftla
vnviakavtqsfmyyvndgvygsfncilydhavvrplpqrepklypssvwgptcdgldqi
veryylpemqvgewllfedmgaytvvgtssfngfqsptiyyvvsglpdhvvrel

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1szrC (C:)
gamdivvnddlscrflegfntrdalckkismntcdegdpffvadlgdivrkhetwkkclp
rvtpfyavkcnddwrvlgtlaalgtgfdcasnteiqrvrgigvppekiiyanpckqishi
ryardsgvdvmtfdcvdelekvakthpkakmvlristddslarcrlsvkfgakvedcrfi
leqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelgfnmhildigggfpg
trdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftlavnviakavtpgvq
tdvgahaesnaqsfmyyvndgvygsfncilydhavvrplpqrepipneklypssvwgptc
dgldqiveryylpemqvgewllfedmgaytvvgtssfngfqsptiyyvvsglpdhvvrel
ksqks

    Sequence, based on observed residues (ATOM records): (download) 
    >1szrC (C:)
gdpffvadlgdivrkhetwkkclprvtpfyavkcnddwrvlgtlaalgtgfdcasnteiq
rvrgigvppekiiyanpckqishiryardsgvdvmtfdcvdelekvakthpkakmvlris
tvkfgakvedcrfileqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelg
fnmhildigggfpgtrdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftl
avnviakavtqsfmyyvndgvygsfncilydhavvrplpqrepipneklypssvwgptcd
gldqiveryylpemqvgewllfedmgaytvvgtssfngfqsptiyyv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1szrD (D:)
gamdivvnddlscrflegfntrdalckkismntcdegdpffvadlgdivrkhetwkkclp
rvtpfyavkcnddwrvlgtlaalgtgfdcasnteiqrvrgigvppekiiyanpckqishi
ryardsgvdvmtfdcvdelekvakthpkakmvlristddslarcrlsvkfgakvedcrfi
leqakklnidvtgvsfhvgsgstdastfaqaisdsrfvfdmgtelgfnmhildigggfpg
trdaplkfeeiagvinnalekhfppdlkltivaepgryyvasaftlavnviakavtpgvq
tdvgahaesnaqsfmyyvndgvygsfncilydhavvrplpqrepipneklypssvwgptc
dgldqiveryylpemqvgewllfedmgaytvvgtssfngfqsptiyyvvsglpdhvvrel
ksqks

    Sequence, based on observed residues (ATOM records): (download) 
    >1szrD (D:)
rflegfntrdalckkisgdpffvadlgdivrkhetwkkclprvtpfyavkcnddwrvlgt
laalgtgfdcasnteiqrvrgigvppekiiyanpckqishiryardsgvdvmtfdcvdel
ekvakthpkakmvlristvkfgakvedcrfileqakklnidvtgvsfhvgsgstdastfa
qaisdsrfvfdmgtelgfnmhildigggfpgtrdaplkfeeiagvinnalekhfppdlkl
tivaepgryyvasaftlavnviakavtpaqsfmyyvndgvygsfncilydhavvrplpqr
epipneklypssvwgptcdgldqiveryylpemqvgewllfedmgaytvvgtssfngfqs
ptiyyvvs