PDB entry 1pjl

View 1pjl on RCSB PDB site
Description: Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+
Class: oxidoreductase
Keywords: oxidoreductase
Deposited on 2003-06-03, released 2003-06-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjla1, d1pjla2
  • Chain 'B':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjlb1, d1pjlb2
  • Chain 'C':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjlc1, d1pjlc2
  • Chain 'D':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjld1, d1pjld2
  • Chain 'E':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjle1, d1pjle2
  • Chain 'F':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjlf1, d1pjlf2
  • Chain 'G':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjlg1, d1pjlg2
  • Chain 'H':
    Compound: NAD-dependent malic enzyme, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: ME2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23368
      • modified residue (28)
      • modified residue (37)
      • modified residue (46)
      • modified residue (74)
      • modified residue (85)
      • modified residue (107)
      • modified residue (176)
      • modified residue (218)
      • modified residue (238)
      • modified residue (324)
      • modified residue (326)
      • modified residue (342)
      • modified residue (406)
      • modified residue (538)
    Domains in SCOPe 2.08: d1pjlh1, d1pjlh2
  • Heterogens: LU, NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pjlA (A:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlA (A:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1pjlB (B:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlB (B:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1pjlC (C:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlC (C:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1pjlD (D:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlD (D:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1pjlE (E:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlE (E:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1pjlF (F:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlF (F:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1pjlG (G:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlG (G:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1pjlH (H:)
mlsrlrvvsttctlacrhlhikekgkplmlnprtnkgmaftlqerqmlglqgllppkiet
qdiqalrfhrnlkkmtsplekyiyimgiqerneklfyrilqddieslmpivytptvglac
sqyghifrrpkglfisisdrghvrsivdnwpenhvkavvvtdgerilglgdlgvygmgip
vgklclytacagirpdrclpvcidvgtdniallkdpfymglyqkrdrtqqyddlidefmk
aitdrygrntliqfedfgnhnafrflrkyrekyctfnddiqgtaavalagllaaqkvisk
pisehkilflgageaalgianlivmsmvenglseqeaqkkiwmfdkygllvkgrkakids
yqepfthsapesipdtfedavnilkpstiigvagagrlftpdviramasinerpvifals
nptaqaectaeeaytltegrclfasgspfgpvkltdgrvftpgqgnnvyifpgvalavil
cntrhisdsvfleaakaltsqltdeelaqgrlypplaniqevsiniaikvteylyankma
frypepedkakyvkertwrseydsllpdvyewpesassppvite

    Sequence, based on observed residues (ATOM records): (download) 
    >1pjlH (H:)
ekgkplmlnprtnkgmaftlqerqmlglqgllppkietqdiqalrfhrnlkkmtspleky
iyimgiqerneklfyrilqddieslmpivytptvglacsqyghifrrpkglfisisdrgh
vrsivdnwpenhvkavvvtdgerilglgdlgvygmgipvgklclytacagirpdrclpvc
idvgtdniallkdpfymglyqkrdrtqqyddlidefmkaitdrygrntliqfedfgnhna
frflrkyrekyctfnddiqgtaavalagllaaqkviskpisehkilflgageaalgianl
ivmsmvenglseqeaqkkiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavn
ilkpstiigvagagrlftpdviramasinerpvifalsnptaqaectaeeaytltegrcl
fasgspfgpvkltdgrvftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsql
tdeelaqgrlypplaniqevsiniaikvteylyankmafrypepedkakyvkertwrsey
dsllpdvyewp