PDB entry 1p8j

View 1p8j on RCSB PDB site
Description: crystal structure of the proprotein convertase furin
Class: hydrolase/hydrolase inhibitor
Keywords: prohormone convertase, spc1, pace, p-domain, chloromethylketone, hydrolase-hydrolase inhibitor complex
Deposited on 2003-05-07, released 2003-07-08
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.188
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8ja1, d1p8ja2
  • Chain 'B':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8jb1, d1p8jb2
  • Chain 'C':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8jc1, d1p8jc2
  • Chain 'D':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8jd1, d1p8jd2
  • Chain 'E':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8je1, d1p8je2
  • Chain 'F':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8jf1, d1p8jf2
  • Chain 'G':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8jg1, d1p8jg2
  • Chain 'H':
    Compound: Furin precursor
    Species: Mus musculus [TaxId:10090]
    Gene: FURIN OR FUR OR PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1p8jh1, d1p8jh2
  • Chain 'J':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'K':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'L':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'M':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'N':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'P':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'Q':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Chain 'R':
    Compound: decanoyl-arg-val-lys-arg-chloromethylketone inhibitor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 1P8J (0-5)
  • Heterogens: NAG, CA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1p8jA (A:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jA (A:)
vyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ddwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevr
kavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgf
ndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1p8jB (B:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jB (B:)
vyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ddwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevr
kavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgf
ndwafmtthswdedpagewvleientseannygtltkftlvlygtape

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1p8jC (C:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jC (C:)
vyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ddwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevr
kavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgf
ndwafmtthswdedpagewvleientseannygtltkftlvlygtap

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1p8jD (D:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jD (D:)
vyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ddwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevr
kavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgf
ndwafmtthswdedpagewvleientseannygtltkftlvlygtap

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1p8jE (E:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jE (E:)
vyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ddwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevr
kavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgf
ndwafmtthswdedpagewvleientseannygtltkftlvlygtap

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1p8jF (F:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jF (F:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtap

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1p8jG (G:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jG (G:)
vyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ddwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevr
kavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgf
ndwafmtthswdedpagewvleientseannygtltkftlvlygtap

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1p8jH (H:)
dvyqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
addwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlev
rkavtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadg
fndwafmtthswdedpagewvleientseannygtltkftlvlygtapegl

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8jH (H:)
yqeptdpkfpqqwylsgvtqrdlnvkeawaqgftghgivvsilddgieknhpdlagnydp
gasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmldg
evtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsif
vwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqnek
qivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlnad
dwatngvgrkvshsygyglldagamvalaqnwttvapqrkciveilvepkdigkrlevrk
avtaclgepnhitrlehvqarltlsynrrgdlaihlispmgtrstllaarphdysadgfn
dwafmtthswdedpagewvleientseannygtltkftlvlygtap

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.