PDB entry 1nhu

View 1nhu on RCSB PDB site
Description: Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor
Class: transferase
Keywords: HEPATITIS C; RNA POLYMERASE; ENZYME INHIBITION, X-RAY Crystallography, TRANSFERASE
Deposited on 2002-12-19, released 2003-03-18
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.219
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hepatitis c virus ns5b RNA-dependent RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1nhua_
  • Chain 'B':
    Compound: hepatitis c virus ns5b RNA-dependent RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1nhub_
  • Heterogens: 153, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1nhuA (A:)
ashhhhhhsmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkv
tfdrlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnls
skavnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcek
malydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtend
irveesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgnt
ltcylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgd
ppqpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgni
imyaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaf
slhsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavkt
klkltpipaasqldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >1nhuA (A:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
dlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1nhuB (B:)
ashhhhhhsmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkv
tfdrlqvlddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnls
skavnhihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcek
malydvvstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtend
irveesiyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgnt
ltcylkasaacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgd
ppqpeydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgni
imyaptlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaf
slhsyspgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavkt
klkltpipaasqldlsgwfvagysggdiyhslsrarpr

    Sequence, based on observed residues (ATOM records): (download) 
    >1nhuB (B:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
dlsgwfvagysggdiyh