PDB entry 1e4e

View 1e4e on RCSB PDB site
Description: d-alanyl-d-lacate ligase
Class: ligase
Keywords: ligase, cell wall, antibiotic resistance, membrane, peptidoglycan synthesis
Deposited on 2000-07-03, released 2001-06-28
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-09-21, with a file datestamp of 2011-09-16.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.183
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: vancomycin/teicoplanin a-type resistance protein vana
    Species: ENTEROCOCCUS FAECIUM [TaxId:1352]
    Gene: VANA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25051
      • conflict (61)
      • conflict (275)
      • conflict (281)
      • conflict (327)
    Domains in SCOPe 2.05: d1e4ea1, d1e4ea2
  • Chain 'B':
    Compound: vancomycin/teicoplanin a-type resistance protein vana
    Species: ENTEROCOCCUS FAECIUM [TaxId:1352]
    Gene: VANA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25051
      • conflict (61)
      • conflict (275)
      • conflict (281)
      • conflict (297)
      • conflict (327)
    Domains in SCOPe 2.05: d1e4eb1, d1e4eb2
  • Heterogens: ADP, PHY, MG, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1e4eA (A:)
mnrikvailfggcseehdvsvksaieiaaninkekyeplyigitksgvwkmcekpcaewe
nencysavlspdkkmhgllvkknheyeinhvdvafsalhgksgedgsiqglfelsgipfv
gcdiqssaicmdksltyivaknagiatpafwvinkddrpvaatftypvfvkparsgssfg
vkkvnsadeldyaiesarqydskilieqavsgcevgcavlgnsaalvvgevdqirlqygi
frihqevepekgsenavitvpadlsaeergriqetvkkiyktlgcrglarvdmflqdngr
ivlnevntlpgftsysryprmmaaagislpelidrlivlalkg

    Sequence, based on observed residues (ATOM records): (download) 
    >1e4eA (A:)
nrikvailfggcseehdvsvksaieiaaninkekyeplyigitksgvwkmcekpcaewen
encysavlspdkkmhgllvkknheyeinhvdvafsalhgksgedgsiqglfelsgipfvg
cdiqssaicmdksltyivaknagiatpafwvinkddrpvaatftypvfvkparsgssfgv
kkvnsadeldyaiesarqydskilieqavsgcevgcavlgnsaalvvgevdqirlqygif
rihqevepekgsenavitvpadlsaeergriqetvkkiyktlgcrglarvdmflqdngri
vlnevntlpgftsysryprmmaaagislpelidrlivlalk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1e4eB (B:)
mnrikvailfggcseehdvsvksaieiaaninkekyeplyigitksgvwkmcekpcaewe
nencysavlspdkkmhgllvkknheyeinhvdvafsalhgksgedgsiqglfelsgipfv
gcdiqssaicmdksltyivaknagiatpafwvinkddrpvaatftypvfvkparsgssfg
vkkvnsadeldyaiesarqydskilieqavsgcevgcavlgnsaalvvgevdqirlqygi
frihqevepekgsenavitvpadlsaeergriqetvkkiyktlgcrglarvdmflqdrgr
ivlnevntlpgftsysryprmmaaagislpelidrlivlalkg

    Sequence, based on observed residues (ATOM records): (download) 
    >1e4eB (B:)
nrikvailfggcseehdvsvksaieiaaninkekyeplyigitksgvwkmcekpcaewen
encysavlspdkkmhgllvkknheyeinhvdvafsalhgksgedgsiqglfelsgipfvg
cdiqssaicmdksltyivaknagiatpafwvinkddrpvaatftypvfvkparsgssfgv
kkvnsadeldyaiesarqydskilieqavsgcevgcavlgnsaalvvgevdqirlqygif
rihqevepekgsenavitvpadlsaeergriqetvkkiyktlgcrglarvdmflqdrgri
vlnevntlpgftsysryprmmaaagislpelidrlivlal