SCOP 1.67: Domain d1udua_: 1udu A:

Lineage for d1udua_ (1udu A:)

1. Root: SCOP 1.67

2. Class a: All alpha proteins [46456] (202 folds)

3. Fold a.125: PDEase [48546] (1 superfamily)
   multihelical; can be divided into three subdomains

4. Superfamily a.125.1: PDEase [48547] (1 family)

5. Family a.125.1.1: PDEase [48548] (4 proteins)
   3',5'-cyclic-nucleotide phosphodiesterase, Pfam 00233

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (3 PDB entries)

8. Domain d1udua_: 1udu A: [99222]

Details for d1udua_

PDB Entry: 1udu, 2.83 Å

PDB Description: Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)

SCOP Domain Sequences for d1udua_:

Sequence, based on SEQRES records:

>d1udua_ a.125.1.1 (A:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens)}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkii
kqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqq
riaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvs
edcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d1udua_ a.125.1.1 (A:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens)}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlal
yikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateff
dqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfplldgcr
knrqkwqalaeqq

Timeline for d1udua_:

• d1udua_ is new in SCOP 1.67
  
• d1udua_ appears in SCOP 1.69
  
• d1udua_ appears in the current release, SCOPe 2.08