SCOPe 2.03: Domain d1r49a2: 1r49 A:431-633,A:719-765

Lineage for d1r49a2 (1r49 A:431-633,A:719-765)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1r49a2: 1r49 A:431-633,A:719-765 [96984]
   Other proteins in same PDB: d1r49a1, d1r49a3
   protein/DNA complex; mutant

Details for d1r49a2

PDB Entry: 1r49, 3.13 Å

PDB Description: human topoisomerase i (topo70) double mutant k532r/y723f

PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1r49a2:

Sequence; same for both SEQRES and ATOM records:

>d1r49a2 d.163.1.2 (A:431-633,A:719-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}
pssrikgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalrag
nekeegetadtvgccslrvehinlhpeldgqeyvvefdflgrdsiryynkvpvekrvfkn
lqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapde
nipakilsynranravailcnhqXsklnfldpritvawckkwgvpiekiynktqrekfaw
aidmadedyef

Timeline for d1r49a2:

• d1r49a2 first appeared in SCOP 1.67
  
• d1r49a2 appears in SCOPe 2.02
  
• d1r49a2 appears in SCOPe 2.04
  
• d1r49a2 appears in the current release, SCOPe 2.08