SCOPe 2.04: Domain d1obha3: 1obh A:1-225,A:418-686

Lineage for d1obha3 (1obh A:1-225,A:418-686)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
   core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.26.1: Nucleotidylyl transferase [52374] (6 families)

5. Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375] (13 proteins)
   contains a conserved all-alpha subdomain at the C-terminal extension

6. Protein Leucyl-tRNA synthetase (LeuRS) [82356] (1 species)

7. Species Thermus thermophilus [TaxId:274] [82357] (3 PDB entries)
   contains a non-conserved insertion (residues 581-633) that forms a separate subdomain; possible rudiment Zn finger

8. Domain d1obha3: 1obh A:1-225,A:418-686 [86775]
   Other proteins in same PDB: d1obha1, d1obha2
   protein/RNA complex; complexed with hg, lms, nva, so4

Details for d1obha3

PDB Entry: 1obh, 2.2 Å

PDB Description: leucyl-trna synthetase from thermus thermophilus complexed with a pre-transfer editing substrate analogue in both synthetic active site and editing site

PDB Compounds: (A:) leucyl-tRNA synthetase

SCOPe Domain Sequences for d1obha3:

Sequence, based on SEQRES records:

>d1obha3 c.26.1.1 (A:1-225,A:418-686) Leucyl-tRNA synthetase (LeuRS) {Thermus thermophilus [TaxId: 274]}
mekynphaieakwqrfweekgfmkakdlpggrgkqyvlvmfpypsgdlhmghlknytmgd
vlarfrrmqgyevlhpmgwdafglpaenaalkfgvhpkdwtyanirqakeslrlmgilyd
wdrevttcepeyyrwnqwiflkmwekglayrakglvnwcpkcqtvlaneqvvegrcwrhe
dtpvekreleqwylritayaerllkdleglnwpekvkamqrawigXrlrdwlisrqrywg
tpipmvhceacgvvpvpeeelpvllpdlkdvedirpkgkspleahpefyettcpkcggpa
krdtdtmdtffdsswyylrytdphndrlpfdpekanawmpvdqyiggvehavlhllysrf
ftkflhdlgmvkveepfqglftqgmvlawtdfgpvevegsvvrlpeptrirleipesals
ledvrkmgaelrphedgtlhlwkpavmskskgngvmvgpfvkeqgadiaritilfaappe
nemvwteegvqgawr

Sequence, based on observed residues (ATOM records):

>d1obha3 c.26.1.1 (A:1-225,A:418-686) Leucyl-tRNA synthetase (LeuRS) {Thermus thermophilus [TaxId: 274]}
mekynphaieakwqrfweekgfmkakdlpgggkqyvlvmfpypsgdlhmghlknytmgdv
larfrrmqgyevlhpmgwdafglpaenaalkfgvhpkdwtyanirqakeslrlmgilydw
drevttcepeyyrwnqwiflkmwekglayrakeqwylritayaerllkdleglnwpekvk
amqrawigXrlrdwlisrqrywgtpipmvhcvvpvpeeelpvllpdlkdvedispleahp
efyettcpkrdtdtmdtffdsswyylrytdphndrlpfdpekanawmpvdqyiggvehav
lhllysrfftkflhdlgmvkveepfqglftqgmvlawtdfgpvevegsvvrlpeptrirl
eipesalsledvrkmgaelrphedgtlhlwkpavmskskgngvmvgpfvkeqgadiarit
ilfaappenemvwteegvqgawr

Timeline for d1obha3:

• d1obha3 first appeared in SCOP 1.65
  
• d1obha3 appears in SCOPe 2.03
  
• d1obha3 appears in SCOPe 2.05
  
• d1obha3 appears in the current release, SCOPe 2.08