SCOPe 2.06: Domain d1nbfe_: 1nbf E:

Lineage for d1nbfe_ (1nbf E:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
   Pfam PF00443

6. Protein Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) [82569] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82570] (4 PDB entries)

8. Domain d1nbfe_: 1nbf E: [80391]
   Other proteins in same PDB: d1nbfc_, d1nbfd_
   complex with ubiquitin aldehyde

Details for d1nbfe_

PDB Entry: 1nbf, 2.3 Å

PDB Description: crystal structure of a ubp-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

PDB Compounds: (E:) Ubiquitin carboxyl-terminal hydrolase 7

SCOPe Domain Sequences for d1nbfe_:

Sequence, based on SEQRES records:

>d1nbfe_ d.3.1.9 (E:) Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) {Human (Homo sapiens) [TaxId: 9606]}
kkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyel
qhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfrgk
mvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglq
eaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpan
yilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddlsv
rhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqk

Sequence, based on observed residues (ATOM records):

>d1nbfe_ d.3.1.9 (E:) Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) {Human (Homo sapiens) [TaxId: 9606]}
kkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyel
qhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfrgk
mvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglq
eaekgvkfltlppvlhlqlmrfmnikindrfefpeqlpldeflqktdpkdpanyilhavl
vhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddlsvrhctnay
mlvyiresklsevlqavtdhdipqqlverlqeekrieaqk

Timeline for d1nbfe_:

• d1nbfe_ first appeared in SCOP 1.63
  
• d1nbfe_ appears in SCOPe 2.05
  
• d1nbfe_ appears in SCOPe 2.07
  
• d1nbfe_ appears in the current release, SCOPe 2.08