Lineage for Superfamily d.3.1: Cysteine proteinases

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2173267Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2173268Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet


  1. 2173269d.3.1.1: Papain-like [54002] (26 proteins)
  2. 2173703d.3.1.2: FMDV leader protease [54037] (2 proteins)
    automatically mapped to Pfam PF05408
  3. 2173726d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
    automatically mapped to Pfam PF00648
  4. 2173758d.3.1.4: Transglutaminase core [54044] (3 proteins)
  5. 2173826d.3.1.5: Arylamine N-acetyltransferase [54047] (2 proteins)
    fold similar to that of the factor XIII catalytic domain
    automatically mapped to Pfam PF00797
  6. 2173876d.3.1.6: Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3 proteins)
    automatically mapped to Pfam PF01088
  7. 2173900d.3.1.7: Adenain-like [54054] (6 proteins)
    Pfam PF02902; Ulp1 protease family
  8. 2173964d.3.1.8: Microbial transglutaminase [75336] (1 protein)
    inverted positions of the catalytic triad Asp and His residues
    automatically mapped to Pfam PF09017
  9. 2173971d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
    Pfam PF00443
  10. 2174029d.3.1.10: Avirulence protein Avrpph3 [102723] (1 protein)
    automatically mapped to Pfam PF03543
  11. 2174033d.3.1.11: Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (2 proteins)
    probably the same as Pfam PF02338, OTU-like cysteine protease, but 1TFF (Uniprot Q96DC9) was not detected by the Pfam model
  12. 2174041d.3.1.12: IgG-specific endopeptidase IdeS (Sib38) [117762] (2 proteins)
    automatically mapped to Pfam PF09028
  13. 2174054d.3.1.13: Lpg0564-like [142864] (1 protein)
    Pfam PF07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
  14. 2174058d.3.1.14: Phytochelatin synthase [142867] (1 protein)
    Pfam PF05023; assosiated Pfam PF09328 (DUF1984) is a part of the same functional unit
  15. 2174065d.3.1.15: CHAP domain [142870] (1 protein)
    Pfam PF05257
  16. 2174078d.3.1.16: NlpC/P60 [142873] (2 proteins)
    Pfam PF00877
  17. 2174087d.3.1.17: PMT C-terminal domain like [159843] (1 protein)
    displays a minimal thiol-protease fold and its catalytic triad; potential redox regulation: the catalytic cysteine can form a disulfide bond with an N-terminal cysteine
  18. 2174094d.3.1.18: MOA C-terminal domain-like [159846] (2 proteins)
    PfamB PB070855
  19. 2174105d.3.1.19: Atu2299-like [159849] (1 protein)
    Pfam PF09641; DUF2026; putative Cys/Ser-His-Asp catalytic triad
  20. 2174109d.3.1.20: M48USP-like [159852] (1 protein)
    Pfam PF04843; Herpesvirus tegument protein, N-terminal conserved region
  21. 2174114d.3.1.21: YiiX-like [159855] (1 protein)
    Pfam PF06520; DUF1105; circularly permuted active site residues compare to papain
  22. 2174119d.3.1.22: Autophagin-like [159858] (3 proteins)
    Pfam PF03416
  23. 2174136d.3.1.23: Papain-like viral protease catalytic domain [310648] (2 proteins)
    C-terminal part of Pfam PF08715
  24. 2174174d.3.1.0: automated matches [191342] (1 protein)
    not a true family

More info for Superfamily d.3.1: Cysteine proteinases

Timeline for Superfamily d.3.1: Cysteine proteinases: