SCOPe 2.05: Domain d1mf8a_: 1mf8 A:

Lineage for d1mf8a_ (1mf8 A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.159: Metallo-dependent phosphatases [56299] (1 superfamily)
   4 layers: alpha/beta/beta/alpha; mixed beta sheets; contains duplication

4. Superfamily d.159.1: Metallo-dependent phosphatases [56300] (13 families)
   different families of this superfamily are groupped in a single Pfam family, Pfam PF00149

5. Family d.159.1.3: Protein serine/threonine phosphatase [56310] (6 proteins)

6. Protein Protein phosphatase-2B (PP-2B, calcineurin A subunit) [56313] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56315] (5 PDB entries)

8. Domain d1mf8a_: 1mf8 A: [79040]
   Other proteins in same PDB: d1mf8b_, d1mf8c_
   complexed with ca, po4

Details for d1mf8a_

PDB Entry: 1mf8, 3.1 Å

PDB Description: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

PDB Compounds: (A:) calmodulin-dependent calcineurin a subunit, alpha isoform

SCOPe Domain Sequences for d1mf8a_:

Sequence; same for both SEQRES and ATOM records:

>d1mf8a_ d.159.1.3 (A:) Protein phosphatase-2B (PP-2B, calcineurin A subunit) {Human (Homo sapiens) [TaxId: 9606]}
avpfppshrltakevfdndgkprvdilkahlmkegrleesvalriitegasilrqeknll
didapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkil
ypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvh
gglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyf
ysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnka
avlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlni

Timeline for d1mf8a_:

• d1mf8a_ first appeared in SCOP 1.63
  
• d1mf8a_ appears in SCOPe 2.04
  
• d1mf8a_ appears in SCOPe 2.06
  
• d1mf8a_ appears in the current release, SCOPe 2.07