PDB entry 1mf8
View 1mf8 on RCSB PDB site
Description: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
Class: hydrolase/isomerase/immunosuppressant
Keywords: hydrolase-isomerase-immunosuppressant complex, calcineurin-cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, hydrolase, isomerase
Deposited on
2002-08-09, released
2002-10-16
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-07-27, with a file datestamp of
2011-07-22.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.25
AEROSPACI score: 0.17
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: calmodulin-dependent calcineurin a subunit, alpha isoform
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d1mf8a_ - Chain 'B':
Compound: calcineurin b subunit isoform 1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d1mf8b_ - Chain 'C':
Compound: Peptidyl-prolyl cis-trans isomerase A
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d1mf8c_ - Chain 'D':
Compound: cyclosporin a
Species: Tolypocladium inflatum, synthetic [TaxId:29910]
Database cross-references and differences (RAF-indexed):
- Heterogens: CA, PO4
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1mf8A (A:)
avpfppshrltakevfdndgkprvdilkahlmkegrleesvalriitegasilrqeknll
didapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkil
ypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvh
gglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyf
ysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnka
avlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlnicsddelgs
eedgfdgataaar
Sequence, based on observed residues (ATOM records): (download)
>1mf8A (A:)
avpfppshrltakevfdndgkprvdilkahlmkegrleesvalriitegasilrqeknll
didapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkil
ypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvh
gglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyf
ysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnka
avlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlni
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1mf8B (B:)
mgneasyplemcshfdadeikrlgkrfkkldldnsgslsveefmslpelqqnplvqrvid
ifdtdgngevdfkefiegvsqfsvkgdkeqklrfafriydmdkdgyisngelfqvlkmmv
gnnlkdtqlqqivdktiinadkdgdgrisfeefcavvggldihkkmvvdv
Sequence, based on observed residues (ATOM records): (download)
>1mf8B (B:)
syplemcshfdadeikrlgkrfkkldldnsgslsveefmslpelqqnplvqrvidifdtd
gngevdfkefiegvsqfsvkgdkeqklrfafriydmdkdgyisngelfqvlkmmvgnnlk
dtqlqqivdktiinadkdgdgrisfeefcavvggldihkkmvvd
- Chain 'C':
Sequence, based on SEQRES records: (download)
>1mf8C (C:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
Sequence, based on observed residues (ATOM records): (download)
>1mf8C (C:)
mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgql
- Chain 'D':
No sequence available.