SCOPe 2.02: Domain d1kewa_: 1kew A:

Lineage for d1kewa_ (1kew A:)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)

7. Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)

8. Domain d1kewa_: 1kew A: [68544]
   complexed with gol, nad, tyd

Details for d1kewa_

PDB Entry: 1kew, 1.8 Å

PDB Description: The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium with thymidine diphosphate bound

PDB Compounds: (A:) dtdp-d-glucose 4,6-dehydratase

SCOPe Domain Sequences for d1kewa_:

Sequence; same for both SEQRES and ATOM records:

>d1kewa_ c.2.1.2 (A:) dTDP-glucose 4,6-dehydratase (RmlB) {Streptococcus suis, serotype 2 [TaxId: 1307]}
mkilitggagfigsavvrhiikntqdtvvnidkltyagnleslsdisesnrynfehadic
dsaeitrifeqyqpdavmhlaaeshvdrsitgpaafietnivgtyallevarkywsalge
dkknnfrfhhistdevygdlphpdevensvtlplftettayapsspysaskassdhlvra
wrrtyglptivtncsnnygpyhfpekliplvilnalegkplpiygkgdqirdwlyvedha
ralhmvvtegkagetynigghnekknldvvfticdlldeivpkatsyreqityvadrpgh
drryaidagkisrelgwkpletfesgirktvewylantqwvnnvksgayqswieqnyegr
q

Timeline for d1kewa_:

• d1kewa_ first appeared in SCOP 1.59
  
• d1kewa_ appears in SCOPe 2.01
  
• d1kewa_ appears in SCOPe 2.03
  
• d1kewa_ appears in the current release, SCOPe 2.08