SCOP 1.63: Domain d1jujd_: 1juj D:

Lineage for d1jujd_ (1juj D:)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family)

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (3 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Escherichia coli [TaxId:562] [55834] (48 PDB entries)

8. Domain d1jujd_: 1juj D: [63300]
   complexed with lya, ump; mutant

Details for d1jujd_

PDB Entry: 1juj, 3 Å

PDB Description: human thymidylate synthase bound to dump and ly231514, a pyrrolo(2,3- d)pyrimidine-based antifolate

SCOP Domain Sequences for d1jujd_:

Sequence; same for both SEQRES and ATOM records:

>d1jujd_ d.117.1.1 (D:) Thymidylate synthase {Escherichia coli}
hgelqylgqiqhilrcgvekddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

Timeline for d1jujd_:

• d1jujd_ first appeared in SCOP 1.57
  
• d1jujd_ appears in SCOP 1.61
  
• d1jujd_ appears in SCOP 1.65
  
• d1jujd_ appears in the current release, SCOPe 2.08