SCOP 1.63: Protein: Lactate dehydrogenase

Lineage for Protein: Lactate dehydrogenase

Root: SCOP 1.63
Class d: Alpha and beta proteins (a+b) [53931] (224 folds)
Fold d.162: Lactate & malate dehydrogenases, C-terminal domain [56326] (1 superfamily)
unusual fold, defines family
Superfamily d.162.1: Lactate & malate dehydrogenases, C-terminal domain [56327] (1 family)
Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (4 proteins)
N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
Protein Lactate dehydrogenase [56339] (11 species)

Species:

Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)
1. Domain for 1ldb:
  - Domain d1ldb_2: 1ldb 163-331 [42141]
    Other proteins in same PDB: d1ldb_1
    complexed with so4
2. Domains for 1ldn:
  1. Domain d1ldna2: 1ldn A:163-330 [42133]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  2. Domain d1ldnb2: 1ldn B:163-330 [42134]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  3. Domain d1ldnc2: 1ldn C:163-330 [42135]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  4. Domain d1ldnd2: 1ldn D:163-330 [42136]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  5. Domain d1ldne2: 1ldn E:163-330 [42137]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  6. Domain d1ldnf2: 1ldn F:163-330 [42138]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  7. Domain d1ldng2: 1ldn G:163-330 [42139]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
  8. Domain d1ldnh2: 1ldn H:163-330 [42140]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
3. Domain for 2ldb:
  - Domain d2ldb_2: 2ldb 163-331 [42142]
    Other proteins in same PDB: d2ldb_1
    complexed with fbp, nad, so4
Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)
1. Domains for 1lld:
  1. Domain d1llda2: 1lld A:150-319 [42144]
    Other proteins in same PDB: d1llda1, d1lldb1
  2. Domain d1lldb2: 1lld B:150-319 [42145]
    Other proteins in same PDB: d1llda1, d1lldb1
    complexed with nad; mutant
2. Domains for 1lth:
  1. Domain d1lthr2: 1lth R:150-319 [42146]
    Other proteins in same PDB: d1lthr1, d1ltht1
  2. Domain d1ltht2: 1lth T:150-319 [42147]
    Other proteins in same PDB: d1lthr1, d1ltht1
    complexed with fbp, nad, oxm; mutant
Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)
1. Domain for 1ldm:
  - Domain d1ldm_2: 1ldm 161-329 [42127]
    Other proteins in same PDB: d1ldm_1
    complexed with nad, oxm
2. Domain for 6ldh:
  - Domain d6ldh_2: 6ldh 161-329 [42128]
    Other proteins in same PDB: d6ldh_1
    complexed with so4
3. Domain for 8ldh:
  - Domain d8ldh_2: 8ldh 161-329 [42129]
    Other proteins in same PDB: d8ldh_1
    complexed with cit
Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (1 PDB entry)
- Domains for 1i0z:
  1. Domain d1i0za2: 1i0z A:161-332 [61496]
    Other proteins in same PDB: d1i0za1, d1i0zb1
  2. Domain d1i0zb2: 1i0z B:161-332 [61498]
    Other proteins in same PDB: d1i0za1, d1i0zb1
    complexed with nai, oxm
Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (1 PDB entry)
- Domains for 1i10:
  1. Domain d1i10a2: 1i10 A:160-331 [61500]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  2. Domain d1i10b2: 1i10 B:160-331 [61502]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  3. Domain d1i10c2: 1i10 C:160-331 [61504]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  4. Domain d1i10d2: 1i10 D:160-331 [61506]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  5. Domain d1i10e2: 1i10 E:160-331 [61508]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  6. Domain d1i10f2: 1i10 F:160-331 [61510]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  7. Domain d1i10g2: 1i10 G:160-331 [61512]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
  8. Domain d1i10h2: 1i10 H:160-331 [61514]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
Lactobacillus casei [TaxId:1582] [56345] (1 PDB entry)
- Domain for 1llc:
  - Domain d1llc_2: 1llc 165-334 [42143]
    Other proteins in same PDB: d1llc_1
    complexed with fbp, so4
Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)
- Domains for 1ez4:
  1. Domain d1ez4a2: 1ez4 A:163-334 [64918]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
  2. Domain d1ez4b2: 1ez4 B:163-335 [64920]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
  3. Domain d1ez4c2: 1ez4 C:163-334 [64922]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
  4. Domain d1ez4d2: 1ez4 D:163-335 [64924]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
    complexed with nad
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (3 PDB entries)
1. Domain for 1ceq:
  - Domain d1ceqa2: 1ceq A:164-329 [42130]
    Other proteins in same PDB: d1ceqa1
2. Domain for 1cet:
  - Domain d1ceta2: 1cet A:164-329 [42131]
    Other proteins in same PDB: d1ceta1
    complexed with clq
3. Domain for 1ldg:
  - Domain d1ldg_2: 1ldg 164-329 [42132]
    Other proteins in same PDB: d1ldg_1
    complexed with nad, oxm
Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)
- Domain for 2ldx:
  - Domain d2ldx_2: 2ldx 160-331 [42126]
    Other proteins in same PDB: d2ldx_1
Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)
1. Domain for 5ldh:
  - Domain d5ldh_2: 5ldh 163-331 [42125]
    Other proteins in same PDB: d5ldh_1
    complexed with cit, nal
2. Domains for 9ldb:
  1. Domain d9ldba2: 9ldb A:163-331 [42123]
    Other proteins in same PDB: d9ldba1, d9ldbb1
  2. Domain d9ldbb2: 9ldb B:163-331 [42124]
    Other proteins in same PDB: d9ldba1, d9ldbb1
    complexed with nad, oxm, so4
3. Domains for 9ldt:
  1. Domain d9ldta2: 9ldt A:163-331 [42121]
    Other proteins in same PDB: d9ldta1, d9ldtb1
  2. Domain d9ldtb2: 9ldt B:163-331 [42122]
    Other proteins in same PDB: d9ldta1, d9ldtb1
    complexed with nad, oxm, so4
Thermotoga maritima [TaxId:243274] [56347] (1 PDB entry)
- Domain for 1a5z:
  - Domain d1a5z_2: 1a5z 164-333 [42148]
    Other proteins in same PDB: d1a5z_1
    complexed with cd, fbp, nad, oxm

More info for Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain:

Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain first appeared (with stable ids) in SCOP 1.55
Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOP 1.61
Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOP 1.65
Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in the current release, SCOPe 2.08