Lineage for Family d.93.1.1: SH2 domain

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices
  4. Superfamily d.93.1: SH2 domain [55550] (2 families) (S)
  5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
    Pfam PF00017

Proteins:

  1. Abl tyrosine kinase [55581] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [55582] (2 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [89998] (1 PDB entry)
  2. Adaptor protein Aps [103139] (1 species)
  3. Beta-chimaerin, N-terminal domain [118052] (1 species)
    includes N-terminal tail and the linker to the next domain
  4. c-src tyrosine kinase [55556] (4 species)
    1. Species Chicken (Gallus gallus) [TaxId:9031] [55558] (4 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [55557] (46 PDB entries)
    3. Species Mouse (Mus musculus) [TaxId:10090] [350470] (1 PDB entry)
    4. Species Rous sarcoma virus [TaxId:11886] [69782] (12 PDB entries)
  5. Carboxyl-terminal src kinase (csk) [75498] (1 species)
  6. Cbl [55587] (1 species)
  7. Crk proto-oncogen [82741] (1 species)
  8. Csk homologous kinase Chk [64345] (1 species)
  9. Ews/fli1 activated transcript 2, Eat2 [89999] (1 species)
  10. GRB2-related adaptor protein 2 (MONA, GRID) [111086] (1 species)
  11. Growth factor receptor-bound protein 10, GRB10 [89994] (1 species)
  12. Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)
  13. Growth factor receptor-bound protein 7 [103135] (1 species)
  14. Hematopoietic SH2 domain containing protein HSH2D [143623] (1 species)
  15. Hemopoetic cell kinase Hck [55565] (1 species)
  16. Itk/tsk protein tyrosine kinase [82743] (1 species)
  17. P55 Blk protein tyrosine kinase [55579] (1 species)
  18. p56-lck tyrosine kinase [55552] (1 species)
  19. Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)
    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)
  20. Phospholipase C-gamma-1 [55577] (2 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [55578] (5 PDB entries)
    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [226824] (3 PDB entries)
  21. Proto-oncogen tyrosine kinase [55573] (1 species)
  22. Shc adaptor protein [55567] (1 species)
  23. STAT homologue [103137] (1 species)
  24. STAT-1 [55583] (1 species)
  25. STAT3b [55585] (1 species)
  26. Suppressor of cytokine signaling 2, SOCS-2 [160562] (1 species)
  27. Suppressor of cytokine signaling 4, SOCS-4 [160564] (1 species)
  28. Syk tyrosine kinase [55575] (1 species)
  29. The Xlp protein Sap [55591] (1 species)
  30. Tyrosine kinase Fyn [55559] (1 species)
  31. Tyrosine phoshatase shp-2 [55589] (1 species)
  32. Tyrosine phosphatase Syp [55561] (1 species)
  33. Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084] (1 species)
  34. Tyrosine-protein kinase zap-70 [89996] (1 species)
  35. automated matches [190202] (2 species)
    not a true protein
    1. Species Human (Homo sapiens) [TaxId:9606] [186949] (18 PDB entries)
    2. Species Mouse (Mus musculus) [TaxId:10090] [187800] (5 PDB entries)

More info for Family d.93.1.1: SH2 domain

Timeline for Family d.93.1.1: SH2 domain: