SCOPe 2.02: Family d.37.1.1: CBS-domain pair

Lineage for Family d.37.1.1: CBS-domain pair

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.37: CBS-domain pair [54630] (1 superfamily)
   duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a

4. Superfamily d.37.1: CBS-domain pair [54631] (2 families)

5. Family d.37.1.1: CBS-domain pair [54632] (21 proteins)
   Pfam PF00571; pairs of CBS domains dimerize to form a stable globular domain, a.k.a. Bateman domain

Proteins:

1. 5'-AMP-activated protein kinase subunit gamma-1, AMPKg [160176] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [160177] (3 PDB entries)
     Uniprot P80385 182-326! Uniprot P80385 23-181

2. Chloride channel protein 5, ClC-5 [160174] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [160175] (1 PDB entry)
     Uniprot P51795 578-746

3. Chloride channel protein, CBS tandem [143138] (1 species)
   contains additional structures between the two CBS repeats

   • Species Marbled electric ray (Torpedo marmorata) [TaxId:7788] [143139] (1 PDB entry)
     Uniprot P21564 527-606! Uniprot P21564 691-770

4. Hypothetical protein MTH1622 [102897] (1 species)

   • Species Methanobacterium thermoautotrophicum [TaxId:145262] [102898] (1 PDB entry)

5. Hypothetical protein Rv2626c [143142] (1 species)

   • Species Mycobacterium tuberculosis [TaxId:1773] [143143] (2 PDB entries)
     Uniprot O06186 2-124

6. Hypothetical protein Ta0289 [102899] (1 species)
   contains extra C-terminal zinc-finger domain

   • Species Thermoplasma acidophilum [TaxId:2303] [102900] (2 PDB entries)

7. Hypothetical protein TM0892, CBS tandem [143136] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [143137] (1 PDB entry)
     Uniprot Q9WZZ4 1-60! Uniprot Q9WZZ4 61-121

8. Hypothetical protein TM0935 [102895] (1 species)

   • Species Thermotoga maritima [TaxId:2336] [102896] (1 PDB entry)

9. Hypothetical protein VC0737 [143140] (1 species)
   Putative acetoin utilization protein AcuB

   • Species Vibrio cholerae [TaxId:666] [143141] (1 PDB entry)
     Uniprot Q9KTZ3 21-83! Uniprot Q9KTZ3 93-159

10. Hypothetical protein YkuL [117881] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [117882] (1 PDB entry)
      Uniprot O31698 9-142

11. Magnesium transporter MgtE [160163] (2 species)

    1. Species Enterococcus faecalis [TaxId:1351] [160165] (1 PDB entry)
       Uniprot Q830V1 136-262

    2. Species Thermus thermophilus [TaxId:274] [160164] (1 PDB entry)
       Uniprot Q5SMG8 132-275

12. Nuclear protein SNF4 [143134] (1 species)
    duplication: comprises four CBS repeats

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [143135] (2 PDB entries)
      Uniprot P12904 181-265

13. Type II inosine monophosphate dehydrogenase CBS domains [54633] (4 species)
    contains tandem repeat of two CBS domains inserted into the catalytic TIM-barrel domain; may be disordered in the crystals

    1. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [64260] (1 PDB entry)

    2. Species Human (Homo sapiens), type I [TaxId:9606] [89899] (1 PDB entry)

    3. Species Human (Homo sapiens), type II [TaxId:9606] [54634] (3 PDB entries)

    4. Species Streptococcus pyogenes [TaxId:1314] [54635] (1 PDB entry)

14. Uncharacterized protein C1556.08c [160166] (1 species)
    consists of 4 CBS units

    • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [160167] (1 PDB entry)
      Uniprot Q10343 182-334! Uniprot Q10343 3-181

15. Uncharacterized protein NE2398 [160172] (1 species)

    • Species Nitrosomonas europaea [TaxId:915] [160173] (1 PDB entry)
      Uniprot Q82SE2 1-127

16. Uncharacterized protein PAE2072 [160178] (1 species)
    2 CBS domains = 1 Bateman domain; binds two adenosine nucleotides per subunit (one per one CBS repeat)

    • Species Pyrobaculum aerophilum [TaxId:13773] [160179] (2 PDB entries)
      Uniprot Q8ZVX8 2-132

17. Uncharacterized protein PH0107 [160168] (1 species)

    • Species Pyrococcus horikoshii [TaxId:53953] [160169] (1 PDB entry)
      Uniprot O57847 4-135

18. Uncharacterized protein PH1780 [160159] (1 species)
    duplication: comprises four CBS repeats

    • Species Pyrococcus horikoshii [TaxId:53953] [160160] (1 PDB entry)
      Uniprot O59416 125-281! Uniprot O59416 126-281

19. Uncharacterized protein SSO3205 [160170] (1 species)
    duplication: comprises four CBS repeats

    • Species Sulfolobus solfataricus [TaxId:2287] [160171] (1 PDB entry)
      Uniprot Q97U20 1-135! Uniprot Q97U20 136-276

20. Uncharacterized protein ST2348 [160161] (1 species)

    • Species Sulfolobus tokodaii [TaxId:111955] [160162] (1 PDB entry)
      Uniprot Q96Y20 1-127

21. automated matches [190627] (4 species)
    not a true protein

    1. Species Geobacillus kaustophilus [TaxId:235909] [188209] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [187902] (1 PDB entry)

    3. Species Pyrococcus horikoshii [TaxId:53953] [188263] (1 PDB entry)

    4. Species Sulfolobus tokodaii [TaxId:273063] [187663] (1 PDB entry)

More info for Family d.37.1.1: CBS-domain pair

Timeline for Family d.37.1.1: CBS-domain pair:

• Family d.37.1.1: CBS-domain pair first appeared (with stable ids) in SCOP 1.55, called Family d.37.1.1: CBS-domain
  
• Family d.37.1.1: CBS-domain pair appears in SCOPe 2.01
  
• Family d.37.1.1: CBS-domain pair appears in SCOPe 2.03
  
• Family d.37.1.1: CBS-domain pair appears in the current release, SCOPe 2.08