Lineage for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2129295Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 2129296Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families) (S)

Families:

  1. 2129297c.66.1.1: COMT-like [53336] (4 protein domains)
  2. 2129372c.66.1.2: RNA methyltransferase FtsJ [53339] (1 protein)
    automatically mapped to Pfam PF01728
  3. 2129377c.66.1.3: Fibrillarin homologue [53342] (1 protein)
    automatically mapped to Pfam PF01269
  4. 2129392c.66.1.4: Hypothetical protein MJ0882 [53345] (1 protein)
    automatically mapped to Pfam PF05175
  5. 2129396c.66.1.5: Glycine N-methyltransferase [53348] (1 protein)
  6. 2129455c.66.1.6: Arginine methyltransferase [53351] (4 protein domains)
    lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain
  7. 2129481c.66.1.7: Protein-L-isoaspartyl O-methyltransferase [53354] (1 protein)
    topological variant; strand order 3214567; strand 6 is antiparallel to the rest
    automatically mapped to Pfam PF01135
  8. 2129502c.66.1.8: Chemotaxis receptor methyltransferase CheR, C-terminal domain [53357] (1 protein)
    contains additional N-terminal all-alpha domain, res. 11-91
    automatically mapped to Pfam PF01739
  9. 2129507c.66.1.11: Type II DNA methylase [53377] (3 protein domains)
    circularly permuted version of the common fold
  10. 2129522c.66.1.12: Plant O-methyltransferase, C-terminal domain [64111] (6 protein domains)
    automatically mapped to Pfam PF00891
  11. 2129582c.66.1.13: tRNA(1-methyladenosine) methyltransferase-like [64117] (5 protein domains)
    contains additional N-terminal beta-sandwich domain
  12. 2129598c.66.1.14: Hypothetical protein HI0319 (YecO) [69544] (2 protein domains)
  13. 2129610c.66.1.15: Arylamine N-methyltransferase [69547] (3 protein domains)
    automatically mapped to Pfam PF01234
  14. 2129700c.66.1.16: Guanidinoacetate methyltransferase [69550] (1 protein)
  15. 2129722c.66.1.17: Spermidine synthase [69557] (3 protein domains)
    contains additional N-terminal tetramerisation all-beta domain, res. 1-71
  16. 2129788c.66.1.18: Mycolic acid cyclopropane synthase [69560] (7 protein domains)
  17. 2129827c.66.1.19: Histamine methyltransferase [75261] (1 protein)
  18. 2129844c.66.1.20: Glucose-inhibited division protein B (GidB) [75264] (1 protein)
    automatically mapped to Pfam PF02527
  19. 2129850c.66.1.21: Hypothetical Protein YjhP [82469] (2 protein domains)
  20. 2129863c.66.1.22: Precorrin-6Y methyltransferase (CbiT) [82472] (1 protein)
  21. 2129896c.66.1.23: MraW-like putative methyltransferases [82475] (1 protein)
  22. 2129906c.66.1.24: rRNA adenine dimethylase-like [88784] (5 protein domains)
  23. 2129933c.66.1.25: mRNA cap methylase [88785] (3 protein domains)
  24. 2129999c.66.1.26: C5 cytosine-specific DNA methylase, DCM [88786] (5 protein domains)
    automatically mapped to Pfam PF00145
  25. 2130054c.66.1.27: DNA methylase TaqI, N-terminal domain [88787] (2 protein domains)
  26. 2130081c.66.1.28: N6 adenine-specific DNA methylase, DAM [88788] (3 protein domains)
    automatically mapped to Pfam PF02086
  27. 2130125c.66.1.29: rRNA methyltransferase AviRa [89738] (1 protein)
    automatically mapped to Pfam PF11599
  28. 2130130c.66.1.30: N5-glutamine methyltransferase, HemK [89743] (2 protein domains)
  29. 2130146c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 protein domains)
  30. 2130172c.66.1.32: Ta1320-like [89751] (2 protein domains)
  31. 2130183c.66.1.33: rRNA methyltransferase RlmA [102557] (1 protein)
  32. 2130188c.66.1.34: mRNA cap (Guanine N-7) methyltransferase [102560] (1 protein)
    mRNA capping enzyme
    automatically mapped to Pfam PF03291
  33. 2130198c.66.1.35: Salicylic acid carboxyl methyltransferase (SAMT) [102563] (1 protein)
    automatically mapped to Pfam PF03492
  34. 2130202c.66.1.36: Thiopurine S-methyltransferase [102566] (1 protein)
    automatically mapped to Pfam PF05724
  35. 2130217c.66.1.37: Leucine carboxy methyltransferase Ppm1 [102569] (1 protein)
  36. 2130236c.66.1.38: NOL1/NOP2/sun [102575] (3 protein domains)
    Pfam PF01189; contains additional N-terminal 3-helical and ferredoxin-like domains
  37. 2130247c.66.1.39: Ribosomal protein L11 methyltransferase PrmA [102578] (1 protein)
    contains additional N-terminal ferredoxin-like domain
    automatically mapped to Pfam PF06325
  38. 2130262c.66.1.40: (Uracil-5-)-methyltransferase [102581] (1 protein)
    Pfam PF05958
  39. 2130268c.66.1.41: UbiE/COQ5-like [110671] (5 protein domains)
    Pfam PF01209
  40. 2130297c.66.1.42: AD-003 protein-like [117685] (3 protein domains)
    Pfam PF05891; DUF858
  41. 2130309c.66.1.43: CAC2371-like [117688] (3 protein domains)
    similar overall fold to the Glycine N-methyltransferase (53348) and mRNA cap (Guanine N-7) methyltransferase (102560) families
  42. 2130322c.66.1.44: TehB-like [142603] (2 protein domains)
    Pfam PF03848; overall structural similarity to Thiopurine S-methyltransferase (Pfam PF05724)
  43. 2130341c.66.1.45: N-6 DNA Methylase-like [142606] (3 protein domains)
    Pfam PF02384; contains C-terminal extension to the canonical fold and extra N-terminal all-alpha domain similar to the insert domain of the DAM family (88788)
  44. 2130353c.66.1.46: YhhF-like [142611] (6 protein domains)
    Pfam PF03602
  45. 2130379c.66.1.47: Met-10+ protein-like [142622] (1 protein)
    Pfam PF02475; contains extra N-terminal alpha+beta domain: beta(2)-alpha-beta(2); mixed beta-sheet; order: 1234; cf (102740)
  46. 2130387c.66.1.48: Nsp15 N-terminal domain-like [142625] (1 protein)
    rudiment methyltransferase fold that probably has lost the enzymatic activity; contains extra N-terminal alpha+beta subdomain
  47. 2130404c.66.1.49: BC2162-like [142629] (2 protein domains)
    contains extra helical regions inserted after strands 5 and 6 of the canonical fold
  48. 2130413c.66.1.50: CmcI-like [142632] (1 protein)
    Pfam PF04989; may have evolved different enzymatic activity
  49. 2130452c.66.1.51: hypothetical RNA methyltransferase [142635] (4 protein domains)
    C-terminal part of Pfam PF03602; similar to (Uracil-5-)-methyltransferase (Pfam PF05958)
  50. 2130478c.66.1.52: RPA4359-like [142644] (1 protein)
    Pfam PF02636; DUF185
  51. 2130483c.66.1.53: TrmB-like [142647] (1 protein)
    Pfam PF02390
  52. 2130491c.66.1.54: Methyltransferase 10 domain [142651] (2 protein domains)
    Pfam PF05971; DUF890
  53. 2130499c.66.1.55: YhiQ-like [159686] (1 protein)
    Pfam PF04445; DUF548; contains extra N-terminal alpha+beta subdomain [beta-alpha-beta(4)]
  54. 2130507c.66.1.56: FkbM-like [159691] (1 protein)
    contains extra N-terminal alpha/beta and all-alpha subdomains
  55. 2130511c.66.1.57: ML2640-like [159694] (2 protein domains)
    Pfam PF02409; O-methyltransferase N-terminus (DUF142); most similar structure to the Leucine carboxy methyltransferase Ppm1 family
  56. 2130520c.66.1.58: TRM1-like [159697] (1 protein)
    Pfam PF02005; contains extra C-terminal alpha+beta subdomain
  57. 2130528c.66.1.59: LPG1296-like [159700] (1 protein)
    Pfam PF04378; DUF519
  58. 2130532c.66.1.60: C-3'-methyltransferase-like [310657] (2 protein domains)
    Pfam PF08421; Pfam PF13489; Pfam PF08484 (in that order in the sequence)
  59. 2130545c.66.1.61: TylF O-methyltransferase-like [310662] (4 protein domains)
    Pfam PF05711
  60. 2130608c.66.1.0: automated matches [191451] (1 protein)
    not a true family

More info for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases

Timeline for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases: