SCOPe 2.08: Family c.66.1.25: mRNA cap methylase

Lineage for Family c.66.1.25: mRNA cap methylase

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.25: mRNA cap methylase [88785] (4 proteins)

Proteins:

1. An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 [89741] (2 species)
   structurally and functionally similar to VP39

   1. Species Flavivirus (Dengue virus type 2) [TaxId:12637] [89742] (8 PDB entries)
      Uniprot P12823 2495-2756

   2. Species Murray valley encephalitis virus (strain mve-1-51) [TaxId:301478] [187362] (6 PDB entries)

2. Polymerase regulatory subunit VP39 [53361] (2 species)

   1. Species Vaccinia virus wr [TaxId:10254] [224905] (2 PDB entries)

   2. Species Vaccinia virus [TaxId:10245] [53362] (17 PDB entries)

3. SARS coronavirus nsp16 [419230] (1 species)
   Pfam PF06460

   • Species SARS-CoV coronavirus [TaxId:227859] [419755] (3 PDB entries)

4. automated matches [190302] (11 species)
   not a true protein

   1. Species Dengue virus 2 16681-pdk53 [TaxId:31635] [188733] (1 PDB entry)

   2. Species Dengue virus 3 [TaxId:11069] [189561] (3 PDB entries)

   3. Species Dengue virus [TaxId:12637] [189508] (1 PDB entry)

   4. Species Human betacoronavirus 2c EMC/2012 [TaxId:1235996] [419989] (12 PDB entries)

   5. Species Human coronavirus oc43 [TaxId:31631] [420140] (1 PDB entry)

   6. Species SARS coronavirus [TaxId:227859] [419868] (1 PDB entry)

   7. Species Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049] [420071] (20 PDB entries)

   8. Species Vaccinia virus [TaxId:10245] [187111] (2 PDB entries)

   9. Species West Nile virus [TaxId:11082] [187969] (2 PDB entries)

   10. Species Zika virus (strain mr 766) [TaxId:64320] [322798] (8 PDB entries)

   11. Species Zika virus [TaxId:64320] [322811] (3 PDB entries)

More info for Family c.66.1.25: mRNA cap methylase

Timeline for Family c.66.1.25: mRNA cap methylase:

• Family c.66.1.25: mRNA cap methylase first appeared in SCOP 1.65
  
• Family c.66.1.25: mRNA cap methylase appears in SCOPe 2.07