SCOPe 2.05: Species: Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773]

Lineage for Species: Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773]

Root: SCOPe 2.05
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Enoyl-ACP reductase [51791] (11 species)
Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (58 PDB entries)

PDB entries in Species: Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773]:

Domain(s) for 1bvr:
1. Domain d1bvra_: 1bvr A: [29913]
  complexed with nad, tht
2. Domain d1bvrb_: 1bvr B: [29914]
  complexed with nad, tht
3. Domain d1bvrc_: 1bvr C: [29915]
  complexed with nad, tht
4. Domain d1bvrd_: 1bvr D: [29916]
  complexed with nad, tht
5. Domain d1bvre_: 1bvr E: [29917]
  complexed with nad, tht
6. Domain d1bvrf_: 1bvr F: [29918]
  complexed with nad, tht
Domain(s) for 1eny:
- Domain d1enya_: 1eny A: [29910]
  complexed with nad
Domain(s) for 1enz:
- Domain d1enza_: 1enz A: [29912]
  complexed with nad
Domain(s) for 1p44:
1. Domain d1p44a_: 1p44 A: [94076]
  complexed with geq, nad
2. Domain d1p44b_: 1p44 B: [94077]
  complexed with geq, nad
3. Domain d1p44c_: 1p44 C: [94078]
  complexed with geq, nad
4. Domain d1p44d_: 1p44 D: [94079]
  complexed with geq, nad
5. Domain d1p44e_: 1p44 E: [94080]
  complexed with geq, nad
6. Domain d1p44f_: 1p44 F: [94081]
  complexed with geq, nad
Domain(s) for 1p45:
1. Domain d1p45a_: 1p45 A: [94082]
  complexed with nad, tcl
2. Domain d1p45b_: 1p45 B: [94083]
  complexed with nad, tcl
Domain(s) for 1zid:
- Domain d1zida_: 1zid A: [29911]
  complexed with zid
Domain(s) for 2aq8:
- Domain d2aq8a_: 2aq8 A: [127166]
  automated match to d1bvra_
  complexed with lys, nai
Domain(s) for 2aqh:
- Domain d2aqha_: 2aqh A: [162857]
  automated match to d1bvra_
  complexed with nai; mutant
Domain(s) for 2aqi:
- Domain d2aqia_: 2aqi A: [162858]
  automated match to d1bvra_
  complexed with nai; mutant
Domain(s) for 2aqk:
- Domain d2aqka_: 2aqk A: [127181]
  automated match to d1bvra_
  complexed with nai; mutant
Domain(s) for 2b35:
1. Domain d2b35a_: 2b35 A: [127767]
  automated match to d1bvra_
  complexed with nad, tcl
2. Domain d2b35b_: 2b35 B: [127768]
  automated match to d1bvra_
  complexed with nad, tcl
3. Domain d2b35c_: 2b35 C: [127769]
  automated match to d1bvra_
  complexed with nad, tcl
4. Domain d2b35d_: 2b35 D: [127770]
  automated match to d1bvra_
  complexed with nad, tcl
5. Domain d2b35e_: 2b35 E: [127771]
  automated match to d1bvra_
  complexed with nad, tcl
6. Domain d2b35f_: 2b35 F: [127772]
  automated match to d1bvra_
  complexed with nad, tcl
Domain(s) for 2b36:
1. Domain d2b36a_: 2b36 A: [127773]
  automated match to d1bvra_
  complexed with 5pp, nad
2. Domain d2b36b_: 2b36 B: [127774]
  automated match to d1bvra_
  complexed with 5pp, nad
3. Domain d2b36c_: 2b36 C: [127775]
  automated match to d1bvra_
  complexed with 5pp, nad
4. Domain d2b36d_: 2b36 D: [127776]
  automated match to d1bvra_
  complexed with 5pp, nad
5. Domain d2b36e_: 2b36 E: [127777]
  automated match to d1bvra_
  complexed with 5pp, nad
6. Domain d2b36f_: 2b36 F: [127778]
  automated match to d1bvra_
  complexed with 5pp, nad
Domain(s) for 2b37:
1. Domain d2b37a_: 2b37 A: [127779]
  automated match to d1bvra_
  complexed with 8ps, nad
2. Domain d2b37b_: 2b37 B: [127780]
  automated match to d1bvra_
  complexed with 8ps, nad
3. Domain d2b37c_: 2b37 C: [127781]
  automated match to d1bvra_
  complexed with 8ps, nad
4. Domain d2b37d_: 2b37 D: [127782]
  automated match to d1bvra_
  complexed with 8ps, nad
5. Domain d2b37e_: 2b37 E: [127783]
  automated match to d1bvra_
  complexed with 8ps, nad
6. Domain d2b37f_: 2b37 F: [127784]
  automated match to d1bvra_
  complexed with 8ps, nad
Domain(s) for 2h9i:
- Domain d2h9ia_: 2h9i A: [136265]
  automated match to d1eny__
  complexed with ead
Domain(s) for 2idz:
- Domain d2idza_: 2idz A: [147641]
  automated match to d1bvra_
  complexed with zid
Domain(s) for 2ie0:
- Domain d2ie0a_: 2ie0 A: [165521]
  automated match to d1bvra_
  complexed with zid; mutant
Domain(s) for 2ieb:
- Domain d2ieba_: 2ieb A: [147642]
  automated match to d1bvra_
  complexed with zid; mutant
Domain(s) for 2ied:
1. Domain d2ieda_: 2ied A: [147643]
  automated match to d1bvra_
  mutant
2. Domain d2iedb_: 2ied B: [147644]
  automated match to d1bvra_
  mutant
3. Domain d2iedc_: 2ied C: [147645]
  automated match to d1bvra_
  mutant
4. Domain d2iedd_: 2ied D: [147646]
  automated match to d1bvra_
  mutant
Domain(s) for 2nsd:
1. Domain d2nsda_: 2nsd A: [148384]
  automated match to d1bvra_
  complexed with 4pi, nad
2. Domain d2nsdb_: 2nsd B: [148385]
  automated match to d1bvra_
  complexed with 4pi, nad
Domain(s) for 2ntj:
1. Domain d2ntja_: 2ntj A: [138581]
  automated match to d1eny__
  complexed with p1h
2. Domain d2ntjb_: 2ntj B: [138582]
  automated match to d1eny__
  complexed with p1h
Domain(s) for 2nv6:
- Domain d2nv6a_: 2nv6 A: [138627]
  automated match to d1eny__
  complexed with zid
Domain(s) for 2pr2:
- Domain d2pr2a_: 2pr2 A: [149796]
  automated match to d1bvra_
  complexed with dg1
Domain(s) for 2x22:
1. Domain d2x22a_: 2x22 A: [169811]
  automated match to d1bvra_
  complexed with dms, nad, tcu
2. Domain d2x22b_: 2x22 B: [169812]
  automated match to d1bvra_
  complexed with dms, nad, tcu
Domain(s) for 2x23:
1. Domain d2x23a_: 2x23 A: [169813]
  automated match to d1bvra_
  complexed with dms, nad, tcu
2. Domain d2x23b_: 2x23 B: [169814]
  automated match to d1bvra_
  complexed with dms, nad, tcu
3. Domain d2x23e_: 2x23 E: [169815]
  automated match to d1bvra_
  complexed with dms, nad, tcu
4. Domain d2x23g_: 2x23 G: [169816]
  automated match to d1bvra_
  complexed with dms, nad, tcu
Domain(s) for 3fne:
1. Domain d3fnea_: 3fne A: [175911]
  automated match to d1bvra_
  complexed with 8pc, nad
2. Domain d3fneb_: 3fne B: [175912]
  automated match to d1bvra_
  complexed with 8pc, nad
3. Domain d3fnec_: 3fne C: [175913]
  automated match to d1bvra_
  complexed with 8pc, nad
4. Domain d3fned_: 3fne D: [175914]
  automated match to d1bvra_
  complexed with 8pc, nad
Domain(s) for 3fnf:
1. Domain d3fnfa_: 3fnf A: [175915]
  automated match to d1bvra_
  complexed with jpm, nad
2. Domain d3fnfb_: 3fnf B: [175916]
  automated match to d1bvra_
  complexed with jpm, nad
3. Domain d3fnfc_: 3fnf C: [175917]
  automated match to d1bvra_
  complexed with jpm, nad
4. Domain d3fnfd_: 3fnf D: [175918]
  automated match to d1bvra_
  complexed with jpm, nad
Domain(s) for 3fng:
- Domain d3fnga_: 3fng A: [175919]
  automated match to d1bvra_
  complexed with jpl, nad
Domain(s) for 3fnh:
- Domain d3fnha_: 3fnh A: [175920]
  automated match to d1bvra_
  complexed with jpj, nad
Domain(s) for 3oew:
- Domain d3oewa_: 3oew A: [182969]
  automated match to d1bvra_
  complexed with mpd, nad
Domain(s) for 3oey:
- Domain d3oeya_: 3oey A: [182974]
  automated match to d1bvra_
  complexed with mpd, nad
Domain(s) for 3of2:
- Domain d3of2a_: 3of2 A: [182975]
  automated match to d1bvra_
  complexed with mpd, nad
Domain(s) for 4bge:
1. Domain d4bgea_: 4bge A: [229364]
  automated match to d2aqka_
  complexed with pyw; mutant
2. Domain d4bgeb_: 4bge B: [229368]
  automated match to d2aqka_
  complexed with pyw; mutant
3. Domain d4bgec_: 4bge C: [229367]
  automated match to d2aqka_
  complexed with pyw; mutant
4. Domain d4bged_: 4bge D: [229363]
  automated match to d2aqka_
  complexed with pyw; mutant
5. Domain d4bgee_: 4bge E: [229362]
  automated match to d2aqka_
  complexed with pyw; mutant
6. Domain d4bgef_: 4bge F: [229370]
  automated match to d2aqka_
  complexed with pyw; mutant
Domain(s) for 4bii:
1. Domain d4biia_: 4bii A: [229371]
  automated match to d1p44a_
  complexed with nad, pyw
2. Domain d4biib_: 4bii B: [229365]
  automated match to d1p44a_
  complexed with nad, pyw
3. Domain d4biic_: 4bii C: [229369]
  automated match to d1p44a_
  complexed with nad, pyw
4. Domain d4biid_: 4bii D: [229366]
  automated match to d1p44a_
  complexed with nad, pyw
Domain(s) for 4bqp:
1. Domain d4bqpa_: 4bqp A: [229515]
  automated match to d1p44a_
  complexed with na, nad, vmy
2. Domain d4bqpb_: 4bqp B: [229512]
  automated match to d1p44a_
  complexed with na, nad, vmy
3. Domain d4bqpc_: 4bqp C: [229509]
  automated match to d1p44a_
  complexed with na, nad, vmy
4. Domain d4bqpd_: 4bqp D: [229513]
  automated match to d1p44a_
  complexed with na, nad, vmy
5. Domain d4bqpe_: 4bqp E: [229514]
  automated match to d1p44a_
  complexed with na, nad, vmy
6. Domain d4bqpf_: 4bqp F: [229511]
  automated match to d1p44a_
  complexed with na, nad, vmy
Domain(s) for 4bqr:
1. Domain d4bqra_: 4bqr A: [229510]
  automated match to d1p44a_
  complexed with ibh, nad
2. Domain d4bqrb_: 4bqr B: [229507]
  automated match to d1p44a_
  complexed with ibh, nad
3. Domain d4bqrc_: 4bqr C: [229508]
  automated match to d1p44a_
  complexed with ibh, nad
4. Domain d4bqrd_: 4bqr D: [229516]
  automated match to d1p44a_
  complexed with ibh, nad
Domain(s) for 4cod:
1. Domain d4codb_: 4cod B: [236702]
  automated match to d1p44a_
  complexed with kv1, nad
2. Domain d4codd_: 4cod D: [236704]
  automated match to d1p44a_
  complexed with kv1, nad
3. Domain d4codf_: 4cod F: [236703]
  automated match to d1p44a_
  complexed with kv1, nad
4. Domain d4codh_: 4cod H: [236705]
  automated match to d1p44a_
  complexed with kv1, nad
Domain(s) for 4d0r:
- Domain d4d0ra_: 4d0r A: [272855]
  automated match to d4tzka_
  complexed with 41i, nad
Domain(s) for 4d0s:
1. Domain d4d0sa_: 4d0s A: [272854]
  automated match to d1p44a_
  complexed with 9g4, mg, nad
2. Domain d4d0sb_: 4d0s B: [272850]
  automated match to d1p44a_
  complexed with 9g4, mg, nad
3. Domain d4d0sc_: 4d0s C: [272853]
  automated match to d1p44a_
  complexed with 9g4, mg, nad
4. Domain d4d0sd_: 4d0s D: [272849]
  automated match to d1p44a_
  complexed with 9g4, mg, nad
Domain(s) for 4dqu:
- Domain d4dqua_: 4dqu A: [193770]
  automated match to d2h7ma_
  complexed with nai; mutant
Domain(s) for 4dre:
- Domain d4drea_: 4dre A: [194609]
  automated match to d2h7ma_
  complexed with nai
Domain(s) for 4dti:
- Domain d4dtia_: 4dti A: [194608]
  automated match to d2ieda_
  complexed with nai; mutant
Domain(s) for 4oim:
- Domain d4oima_: 4oim A: [257259]
  automated match to d2h7ma_
  complexed with act, jus, nad
Domain(s) for 4qxm:
1. Domain d4qxma_: 4qxm A: [275213]
  automated match to d1p44a_
  complexed with 713, nad
2. Domain d4qxmc_: 4qxm C: [275214]
  automated match to d1p44a_
  complexed with 713, nad
3. Domain d4qxme_: 4qxm E: [275216]
  automated match to d1p44a_
  complexed with 713, nad
4. Domain d4qxmg_: 4qxm G: [275217]
  automated match to d1p44a_
  complexed with 713, nad
Domain(s) for 4r9r:
1. Domain d4r9ra_: 4r9r A: [268685]
  automated match to d4tzka_
  complexed with 3kx, nad
2. Domain d4r9rc_: 4r9r C: [268686]
  automated match to d4tzka_
  complexed with 3kx, nad
3. Domain d4r9re_: 4r9r E: [268683]
  automated match to d4tzka_
  complexed with 3kx, nad
4. Domain d4r9rg_: 4r9r G: [268684]
  automated match to d4tzka_
  complexed with 3kx, nad
Domain(s) for 4trj:
- Domain d4trja_: 4trj A: [259027]
  automated match to d1p44a_
  complexed with 665, nad
Domain(s) for 4trm:
1. Domain d4trma_: 4trm A: [271980]
  automated match to d1p44a_
  complexed with mes
2. Domain d4trmb_: 4trm B: [271979]
  automated match to d1p44a_
  complexed with mes
3. Domain d4trmc_: 4trm C: [271970]
  automated match to d1p44a_
  complexed with mes
4. Domain d4trmd_: 4trm D: [271972]
  automated match to d1p44a_
  complexed with mes
5. Domain d4trme_: 4trm E: [271969]
  automated match to d1p44a_
  complexed with mes
6. Domain d4trmf_: 4trm F: [271968]
  automated match to d1p44a_
  complexed with mes
Domain(s) for 4trn:
- Domain d4trna_: 4trn A: [271984]
  automated match to d1p44a_
  complexed with dms, mpd, nad
Domain(s) for 4tro:
- Domain d4troa_: 4tro A: [271971]
  automated match to d1p44a_
  complexed with dms, epe, na, nad, zid
Domain(s) for 4tzk:
- Domain d4tzka_: 4tzk A: [259114]
  automated match to d1p44a_
  complexed with 641, nad
Domain(s) for 4tzt:
- Domain d4tzta_: 4tzt A: [259113]
  automated match to d1p44a_
  complexed with 468, nad
Domain(s) for 4u0j:
- Domain d4u0ja_: 4u0j A: [258542]
  automated match to d1p44a_
  complexed with 566, nad
Domain(s) for 4u0k:
- Domain d4u0ka_: 4u0k A: [258544]
  automated match to d1p44a_
  complexed with 744, nad
Domain(s) for 4uvd:
- Domain d4uvda_: 4uvd A: [277592]
  automated match to d1p44a_
  complexed with hrw, mg, nad
Domain(s) for 4uve:
- Domain d4uvea_: 4uve A: [277593]
  automated match to d1p44a_
  complexed with ki5, mg, nad
Domain(s) for 4uvg:
- Domain d4uvga_: 4uvg A: [277587]
  automated match to d1p44a_
  complexed with 1pe, a0c, mg, nad
Domain(s) for 4uvh:
1. Domain d4uvha_: 4uvh A: [277589]
  automated match to d1p44a_
  complexed with act, nad, uud
2. Domain d4uvhb_: 4uvh B: [277585]
  automated match to d1p44a_
  complexed with act, nad, uud
3. Domain d4uvhc_: 4uvh C: [277591]
  automated match to d1p44a_
  complexed with act, nad, uud
4. Domain d4uvhd_: 4uvh D: [277590]
  automated match to d1p44a_
  complexed with act, nad, uud
Domain(s) for 4uvi:
1. Domain d4uvia_: 4uvi A: [277584]
  automated match to d1p44a_
  complexed with kxu, nad
2. Domain d4uvib_: 4uvi B: [277583]
  automated match to d1p44a_
  complexed with kxu, nad
3. Domain d4uvic_: 4uvi C: [277588]
  automated match to d1p44a_
  complexed with kxu, nad
4. Domain d4uvid_: 4uvi D: [277586]
  automated match to d1p44a_
  complexed with kxu, nad
Domain(s) for 5cp8:
- Domain d5cp8a_: 5cp8 A: [275601]
  automated match to d4tzka_
  complexed with epe, ete, nad, tcu; mutant

More info for Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] from c.2.1.2 Enoyl-ACP reductase

Timeline for Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] from c.2.1.2 Enoyl-ACP reductase:

Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] from c.2.1.2 Enoyl-ACP reductase first appeared (with stable ids) in SCOP 1.55
Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] from c.2.1.2 Enoyl-ACP reductase appears in SCOPe 2.04
Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] from c.2.1.2 Enoyl-ACP reductase appears in SCOPe 2.06
Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] from c.2.1.2 Enoyl-ACP reductase appears in the current release, SCOPe 2.08