SCOPe 2.02: Family b.85.4.1: dUTPase-like

Lineage for Family b.85.4.1: dUTPase-like

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.85: beta-clip [51268] (7 superfamilies)
   double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll

4. Superfamily b.85.4: dUTPase-like [51283] (2 families)
   forms tight trimer through an additional beta-sheet in each subunit
   subunit beta-sheets are orthogonally packed around the three-fold axis

5. Family b.85.4.1: dUTPase-like [51284] (5 proteins)

Proteins:

1. Bifunctional dCTP deaminase/dUTPase [89425] (1 species)
   elaborated fold with additional structures

   • Species Methanococcus jannaschii [TaxId:2190] [89426] (5 PDB entries)
     synonym: Methanocaldococcus jannaschii

2. Deoxycytidine triphosphate deaminase (dCTP deaminase) [117335] (2 species)

   1. Species Escherichia coli [TaxId:562] [117336] (6 PDB entries)
      Uniprot P28248

   2. Species Mycobacterium tuberculosis [TaxId:83332] [188349] (2 PDB entries)

3. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) [51285] (7 species)

   1. Species Equine infectious anemia virus [TaxId:11665] [51288] (2 PDB entries)

   2. Species Escherichia coli [TaxId:562] [51286] (10 PDB entries)
      Uniprot P06968

   3. Species Feline immunodeficiency virus [TaxId:11673] [51287] (8 PDB entries)

   4. Species Human (Homo sapiens) [TaxId:9606] [102010] (4 PDB entries)

   5. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141654] (1 PDB entry)
      Uniprot Q8II92 1-159

   6. Species Mycobacterium tuberculosis, rv2697c [TaxId:1773] [82213] (8 PDB entries)

   7. Species Vaccinia virus [TaxId:10245] [187961] (5 PDB entries)

4. Monomeric viral dUTPase [141655] (1 species)
   related to the trimeric dUTPase domain by domain duplication, fusion and partial deletion; retains only one of the three ancestral active sites

   • Species Epstein-Barr virus [TaxId:10376] [141656] (2 PDB entries)
     Uniprot P03195 121-256! Uniprot P03195 4-116
     Human herpesvirus 4

5. automated matches [190798] (4 species)
   not a true protein

   1. Species Chlorella variabilis [TaxId:554065] [195003] (1 PDB entry)

   2. Species Coxiella burnetii [TaxId:777] [196147] (1 PDB entry)

   3. Species Mycobacterium tuberculosis [TaxId:1773] [189128] (4 PDB entries)

   4. Species Plasmodium falciparum [TaxId:36329] [188061] (2 PDB entries)

More info for Family b.85.4.1: dUTPase-like

Timeline for Family b.85.4.1: dUTPase-like:

• Family b.85.4.1: dUTPase-like first appeared (with stable ids) in SCOP 1.55, called Family b.85.4.1: Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)
  
• Family b.85.4.1: dUTPase-like appears in SCOPe 2.01
  
• Family b.85.4.1: dUTPase-like appears in SCOPe 2.03
  
• Family b.85.4.1: dUTPase-like appears in the current release, SCOPe 2.08